Journal of Research in Medical Sciences1735-199518620130709Anti-phospholipase A2 receptor antibody in idiopathic membranous nephropathy: New concepts459461ENDepartment of Nephrology, Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran20130708-http://jrms.mui.ac.ir/index.php/jrms/article/view/9273http://jrms.mui.ac.ir/index.php/jrms/article/download/9273/3917Journal of Research in Medical Sciences1735-199518620130709Diagnostic value of P63 in differentiating normal gestation from molar pregnancy462466ENDepartment of Pathology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran20130708<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Background:</span></strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Considering the limitations of current pathologic methods in distinguishing two subtypes of hydatidiform mole and non-molar pregnancy, the utility of immunohistochemical markers in this regards and the importance of differentiating of mentioned pathologic patterns, in this study the expression of P63 in patients with complete hydatidiform mole (CHM), partial hydatidiform mole (PHM) and non-molar pregnancy was determined. </span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Materials and</span></strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> <strong style="mso-bidi-font-weight: normal;">Methods:<em><span style="mso-bidi-font-weight: bold;"> </span></em></strong>In<strong><em> </em></strong>this<strong><em> </em></strong>study,<strong><em> </em></strong>formalin-fixed<strong><em> </em></strong>and<strong><em> </em></strong>paraffin-embedded<strong><em> </em></strong>tissues<strong><em> </em></strong>of<strong><em> </em></strong>61<strong><em> </em></strong>patients<strong><em> </em></strong>with<strong><em> </em></strong>definitive<strong><em> </em></strong>pathologic<strong><em> </em></strong>diagnosis<strong><em> </em></strong>of<strong><em> </em></strong>CHM,<strong><em> </em></strong>PHM<strong><em> </em></strong>and<strong><em> </em></strong>non-molar<strong><em> </em></strong>pregnancy<strong><em> </em></strong>retrieved.<strong><em> </em></strong>Diagnoses<strong><em> </em></strong>were<strong><em> </em></strong>based<strong><em> </em></strong>on<strong><em> </em></strong>the<strong><em> </em></strong>study<strong><em> </em></strong>of<strong><em> </em></strong>hematoxylin<strong><em> </em></strong>and<strong><em> </em></strong>eosin<strong><em> </em></strong>stained<strong><em> </em></strong>slides.<strong><span style="mso-bidi-font-style: italic;"> </span></strong>Sections<strong><em> </em></strong>from<strong><em> </em></strong>all<strong><em> </em></strong>samples<strong><em> </em></strong>were<strong><em> </em></strong>stained<strong><em> </em></strong>for<strong><em> </em></strong>P63<strong><em> </em></strong>marker<strong><em> </em></strong>using<strong><em> </em></strong>immunohistochemistry<strong><em> </em></strong>method.<strong><em> </em></strong>The<strong><em> </em></strong>nuclear<strong><em> </em></strong>immune reactivity<strong><em> </em></strong>of<strong><em> </em></strong>P63<strong><em> </em></strong>marker<strong><em> </em></strong>in<strong><em> </em></strong>the<strong><em> </em></strong>three<strong><em> </em></strong>pathologic<strong><em> </em></strong>groups<strong><em> </em></strong>was<strong><em> </em></strong>determined<strong><em> </em></strong>by<strong><em> </em></strong>two<strong><em> </em></strong>pathologists.<span style="mso-bidi-font-weight: bold;"> </span></span></li><li><strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Results:</span></strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> P63 immune-staining was used to evaluate 20, 26 and 15 non-molar pregnancy, CHM and PHM cases, respectively. Mean ± SD of P63 nuclear immune-staining in molar pregnancy (CHM and PHM) and non-molar pregnancy were 32.4 ± 17.4 and 18.9 ± 17.2, respectively (<em style="mso-bidi-font-style: normal;">P</em> = 0.006). The means were significantly different between non-molar pregnancy and PHM (<em style="mso-bidi-font-style: normal;">P</em> < 0.000), CHM and PHM (<em style="mso-bidi-font-style: normal;">P</em> = 0.02) and non-molar pregnancy and CHM (<em style="mso-bidi-font-style: normal;">P</em> = 0.04).<span style="mso-bidi-font-weight: bold;"> </span></span></li><li><strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Conclusion:</span></strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Considering the findings of the current study, though the nuclear immunoreactivity of P63 was higher in molar than non-molar pregnancy and in PHM than CHM, but using this marker alone is not suitable as a diagnostic test due to its low sensitivity and specificity. It could be used as adjuvant test in conflict cases. It is recommended to evaluate the role of other immunohistochemical markers like Ki-67 in this regard.</span></li><li><strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Key</span></strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> <strong>words<span style="text-transform: uppercase;">:</span></strong><span style="text-transform: uppercase;"> c</span>omplete hydatidiform mole, </span><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9274http://jrms.mui.ac.ir/index.php/jrms/article/download/9274/3918Journal of Research in Medical Sciences1735-199518620130709Sex based serum C reactive protein levels and white blood cell count in the subjects with the metabolic syndrome467472ENIsfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranBehavioural sciences research centre, Baqiyatallh Medical Sciences University, Tehran, IranDepartment of Cardiology, Cardiac Rehabilitation Research Center, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranMedical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran20130708<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">Background:</span></strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;"> C</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">reactive Protein (CRP) and white blood cell (WBC) are pro-inflammatory markers. They are major pathophysiological for the development of metabolic syndrome (MetS). This study aimed to address the independent associations between MetS and WBC counts and serum CRP levels and evaluation of their magnitude in relation to the MetS, based on the sex in the Iranian adults. </span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">Materials and Methods: </span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">In this cross sectional study, subjects who met the MetS criteria, based on the ATPIII were selected from the Isfahan Healthy Heart Program database. A questionnaire containing the demographic data, weight, height, waist and hip circumference of the respondents was completed for each person. Blood pressure was measured and the anthropometric measurements were done, and fasting blood samples were taken for two hours post load plasma glucose (2 hpp). Serum (total, HDL and LDL) levels of cholesterol, triglyceride and CRP as well as WBC counts were determined. The univariate analyses were carried out to assess the relation between the CRP levels, WBC counts with the MetS in both sexes the. </span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">Results: </span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">In men with the abdominal obesity, the higher levels of WBC count, high serum triglyceride and blood glucose levels, a low serum HDL level, and raised systolic and diastolic blood pressure were observed. However, the higher serum CRP levels were only observed in those with the low serum HDL-cholesterol levels. The mean values of the WBC counts were statistically different between the men with and without MetS, but the mean values of the CRP levels were similar between the two groups. In women, the mean values of WBC count and CRP levels were statistically different in the subjects with and without a MetS components (except for the low serum HDL levels and high diastolic blood pressure for the WBC measures and abdominal obesity for the CRP measures) and for those with and without MetS.</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> The age and smoking adjusted changes in the </span><span class="highlight"><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">CRP</span></span><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> levels and WBC counts correlated with the number of Mets components in the women.</span><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;"> </span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">Conclusion: </span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">The findings of this study suggest substantial implications for the prevention and management of the MetS and atherosclerotic diseases, as these involve the suppression of inflammatory conditions rather than the incitement of anti-inflammatory conditions.</span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">Keywords:</span></strong><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;"> </span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">C-reactive protein level, metabolic syndrome, white Blood Cell Count</span></li></ul><!--[if gte mso 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font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} --> <!--[endif] -->http://jrms.mui.ac.ir/index.php/jrms/article/view/9276http://jrms.mui.ac.ir/index.php/jrms/article/download/9276/3919Journal of Research in Medical Sciences1735-199518620130709The association between reflux esophagitis and airway hyper-reactivity in patients with gastro-esophageal reflux473476ENBaqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IranChemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranChemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranDepartment of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran20130708<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> 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We aimed to evaluate the effect of GER-induced esophagitis on airway hyper-reactivity (AHR) in patients and the response to treatment. </span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Materials and Methods: </span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">In this cohort study, 30 patients attending the gastrointestinal clinic of a university hospital with acid reflux symptoms were included. All patients were evaluated endoscopically and divided into case group with esophagitis and control group without any evidence of esophagitis. Spirometry and methacholine test were done in all patients before and after treatment of GER with pantoprazole 40 mg daily for six months. </span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Results: </span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">There was a significant difference in the rate of positive methacholine test between the cases (40%) and the controls (6.7%) prior to anti-acid therapy (<em style="mso-bidi-font-style: normal;">P</em><0.0001). After six months of treatment, the frequency of positive methacholine test diminished from 40 to 13.3% in the case group (<em style="mso-bidi-font-style: normal;">P</em> value < 0.05) but did not change in the controls (<em style="mso-bidi-font-style: normal;">P</em>=0.15).</span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Conclusion: </span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">The presence of esophagitis due to GER would increase the AHR and treatment with pantoperazole would decrease AHR in patients with proved esophagitis and no previous history of asthma after six months.</span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Key words: </span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Airway hyper-reactivity, gastroesophageal reflux, methacholine test, spirometry</span></li></ul><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9277http://jrms.mui.ac.ir/index.php/jrms/article/download/9277/3920Journal of Research in Medical Sciences1735-199518620130709Comparing the efficacy of Emu oil with clotrimazole and hydrocortisone in the treatment of seborrheic dermatitis: A clinical trial477481ENDepartment of Dermatology, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Dermatology, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Dermatology, Isfahan University of Medical Sciences, Isfahan, IranPsychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran20130708<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Background: </span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Seborrheic dermatitis (SD) is a common, chronic inflammatory disease. Inflammatory reaction and oxidative stress are thought to be effective in the pathogenesis of SD. Based on anti-inflammatory and anti-oxidant properties of emu oil, this study was designed to evaluate effects of emu oil on patients suffering from SD, and to compare it with routine treatments of SD with topical steroids and antifungal agents.<strong> </strong></span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Materials and</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> <strong>Methods:</strong> This clinical trial was conducted on126 patients who were randomly allocated to 2 groups:62 in the clotrimazole vs. emu oil( group-1) and 64 in the hydrocortisone vs. emu oil( group-2). The right side of the face in both groups was treated with topical emu oil. The left side was treated with topical clotrimazole in the first group and with topical hydrocortisone in the second group. One month after the treatment, pre and post treatment symptom severity scores of pruritus, erythema and scales were compared.</span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Results: </span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">All 3 medications significantly improved pruritus, erythema and scales (p<0. 01). However, topical clotrimazole and hydrocortisone were significantly more effective than emu oil in improving scales (p<0.01 ), and hydrocortisone was significantly more effective than emu oil in reducing pruritus (p<0. 01). Comparing with topical clotrimazole, emu oil resulted in significantly more improvement of erythema (p:0.01).</span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Conclusion:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Emu oil is a potentially useful agent that significantly improves itching, erythema and scales associated with SD; however, it was less effective than hydrocortisone and clotrimazole which are routinely prescribed to treat SD. </span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Key words:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> Emu oil, seborrehic dermatitis, therapy</span></li></ul><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 3" /> <w:LsdException Locked="false" 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9278http://jrms.mui.ac.ir/index.php/jrms/article/download/9278/3921Journal of Research in Medical Sciences1735-199518620130709Effect of acupressure of Ex-Le7 point on pain, nausea and vomiting after appendectomy: A randomized trial482486ENDepartments of Medical-Surgical Nursing, Faculty of Nursing, Kashan University of Medical Sciences, Kashan, IranDepartments of Medical-Surgical Nursing, Faculty of Nursing, Kashan University of Medical Sciences, Kashan, Iran20130708<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><strong><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Background:</span></strong><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">The<span style="mso-bidi-font-weight: bold;"> </span>Le7 acupoint had been known as an acupoint for reducing pain of appendicitis. However, no study on the effect of its acupressure on post-appendectomy pain is available. The objective of this study was to evaluate the effects of acupressure of Le7 acupoint on pain, nausea, and vomiting after appendectomy. </span></li><li><strong><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Materials</span></strong><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> <strong>and</strong> <strong>Methods:</strong> </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">A single-blind randomized controlled trial was conducted on 70 post-appendectomy</span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">patients in a general surgical ward. Patients with inclusion criteria were selected consecutively and were randomly assigned into two groups. The intervention group received acupressure to the Le7 acupoint and the second group was the control group. The severity of post-operative pain, nausea, and vomiting measured hourly till the seventh post-operative hour. <em style="mso-bidi-font-style: normal;">T</em>-test was used to compare the mean of pain and nausea severity of two groups. Paired <em style="mso-bidi-font-style: normal;">t</em>-test was used to compare the mean of pain intensity of each group before and total mean of pain at post-intervention hours. Chi-squared test and Fisher exact test were used for nominal data. </span></li><li><strong><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Results:</span></strong><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">The mean of pain intensity in the intervention group was 5.10 ± 3.52 b</span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: "Times New Roman"; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">efore intervention</span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> and </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: "Times New Roman"; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">decreased to 3.53 ± 0.75 in the post-operative hours (<em style="mso-bidi-font-style: normal;">P</em> = 0.018). The mean of pain intensity in the control group was 4.45 ± </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">3.16</span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: "Times New Roman"; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;"> </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">b</span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: "Times New Roman"; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">efore intervention</span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> and changed to </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: "Times New Roman"; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">4.01 ± 0.92 in the post-operative hours (<em style="mso-bidi-font-style: normal;">P</em> = 0.32). However, </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">the mean of pain intensity in the intervention group was less than the control group till 6<sup>th</sup> h after the surgery. No significant differences were observed between the two groups in terms of nausea and vomiting (<em style="mso-bidi-font-style: normal;">P</em> = 0.74).<strong> </strong></span></li><li><strong><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Conclusion<span style="text-transform: uppercase;">:</span></span></strong><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: "Times New Roman"; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; text-transform: uppercase;"> </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; text-transform: uppercase;">a</span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">cupressure on Le7 acupoint was effective on post-appendectomy pain but did not affect nausea and vomiting. Further investigations are suggested with starting acupressure at the onset of pain or nausea and vomiting.</span></li><li><strong><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Key words:</span></strong><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> </span><span style="font-size: 13.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Acupressure, appendectomy, Ex-Le7 point, nausea, pain, vomiting</span></li></ul><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9279http://jrms.mui.ac.ir/index.php/jrms/article/download/9279/3923Journal of Research in Medical Sciences1735-199518620130709Methylenetetrahydrofolate reductase C677T mutation and risk of retinal vein thrombosis487491ENDepartment of Laboratory Sciences, School of Paramedical & Health, Zanjan University of Medical Sciences, Zanjan, Iran1Department of Molecular Genetics, National Research Centre for Genetic Engineering and Biotechnology, Tehran, IranDepartment of Medical Physics, Faculty of Medical Sciences, Iran University of Medical Sciences, Tehran, IranDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranDepartment of Biochemistry, Iranian Blood Transfusion Organization, Tehran, IranDepartment of Biochemistry, Faculty of Medical Sciences, Tehran University of Medical Sciences, Tehran, IranDepartment of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranDepartment of Molecular Medicine, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran20130708<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Background:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Elevated plasma homocysteine (Hcy) level has been established as a significant risk factor for venous thrombosis and cardiovascular disease<span style="mso-bidi-font-weight: bold;">. </span>Homozygosity for the methylenetetrahydrofolate reductase (MTHFR) C677T mutation has been associated with elevated plasma Hcy concentration and may contribute to retinal vein thrombosis (RVT) development. The aim of the present study was to investigate whether the hyperhomocysteinemia and/or homozygosity for the MTHFR C677T mutation are associated with an increased risk for RVT. </span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Materials</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> <strong>and</strong> <strong>Methods:</strong><span style="mso-bidi-font-style: italic;"> </span></span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Our study population consisted of 73 consecutive patients (50-78</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;"> years old</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">) with RVT and 73 control subjects (51</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">-80 years old)</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">, matched for age and sex. Genotyping for the MTHFR C677T mutation was performed by polymerase chain reaction-restriction fragment length polymorphism technique and Hcy level was determined by an enzyme immunoassay kit. </span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Results:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> T</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">he prevalence</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> of 677TT genotype</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;"> was higher in patients than control subjects, but the difference in frequency didn’t reach a significant value (<em style="mso-bidi-font-style: normal;">P</em> = 0.07). The frequency of the </span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">677T </span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">allele was 26% and 21.2% in patients and controls, respectively and did not differ significantly between the two groups (odds ratio = </span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">1.3, 95% confidence interval (</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">0.75-2.24), <em style="mso-bidi-font-style: normal;">P</em> = 0.33). </span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Fasting plasma total Hcy level was significantly higher in patients than controls (<em style="mso-bidi-font-style: normal;">P</em> = 0.001). </span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Conclusion:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-style: italic;"> </span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Our study demonstrated that hyperhomocysteinemia, but not the MTHFR C677T mutation, is associated with RVT.</span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Key words:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Methylenetetrahydrofolate reductase, mutation, polymerase chain reaction-restriction fragment length polymorphism, retinal vein thrombosis, thrombophilia</span></li></ul><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2" /> <w:LsdException Locked="false" Priority="9" QFormat="true" 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9280http://jrms.mui.ac.ir/index.php/jrms/article/download/9280/3922Journal of Research in Medical Sciences1735-199518620130709Validity, reliability, and factor analysis of Persian version of quality of life questionnaire for irritable bowel syndrome (IBS-QOL-34)492496ENBehavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, IranBehavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, IranPsychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, IranPsychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, IranBehavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, IranPsychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, IranIntegrative Functional,Gastroentrology Research Center, Isfahan, Iran20130708<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><strong><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Background</span></strong><span class="hps"><strong><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">:</span></strong></span><span class="hps"><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> </span></span><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;">Quality of life (QOL) improvement is <span class="hps">the main objective of treating patients with irritable bowel syndrome (IBS)</span>. </span><span class="hps"><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">This study</span></span><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> aimed to assess the <span class="hps">validity, reliability,</span> <span class="hps">and</span> <span class="hps">factor analysis</span> <span class="hps">of IBS-QOL-34 questionnaire</span> as a common transcultural instrument for Iranian <span class="hps">IBS</span> patients. </span></li><li><span class="hps"><strong><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Materials and Methods: </span></strong></span><span class="hps"><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;">Two hundred and forty patients with</span></span><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> IBS (based on gastroenterologists’ diagnosis according to<span class="hps"> ROM III criteria) were referred to Digestive Health Clinic in Psychosomatic Research Center have been selected in this study</span></span><span class="hps"><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">. <span style="mso-bidi-font-weight: bold;">Aside with</span> <span style="mso-bidi-font-weight: bold;">IBS-QOL-34,</span></span></span><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> MOS 36-item short-form health survey (SF-36)<span class="hps"> and IBS severity index (IBSSI) questionnaires</span> were completed by the cases</span><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> for determination of <span style="mso-bidi-font-weight: bold;">correlation coefficients</span>; the data were analyzed using descriptive statistics, factor <span class="hps">analysis</span>, <span class="hps">Cronbach’s alpha, Pearson</span> <span class="hps">correlation coefficient by Statistical Package for Social Sciences (SPSS) software, version 18</span>. </span></li><li><span class="hps"><strong><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Results:</span></strong></span><span class="hps"><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> </span></span><span class="hps"><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Total reliability of the questionnaire was reported by using Cronbach’s alpha as 0.95, ranging from 0.65 to 0.90. Correlation coefficients</span></span><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> <span class="hps">of</span> concurrent <span class="hps">implementation of IBS-QOL with</span> SF-36 and <span class="hps">IBSSI resulted in</span> </span><span class="hps"><span style="font-size: 12.0pt; line-height: 115%; font-family: Symbol; mso-ascii-font-family: "Times New Roman"; mso-ascii-theme-font: major-bidi; mso-hansi-font-family: "Times New Roman"; mso-hansi-theme-font: major-bidi; mso-char-type: symbol; mso-symbol-font-family: Symbol;"><span style="mso-char-type: symbol; mso-symbol-font-family: Symbol;">-</span></span></span><span class="hps"><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">0.61 and</span></span><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> 0.64<span class="hps">, respectively. Exploratory factor analysis</span> <span class="hps">using</span> <span class="hps">varimax rotation</span> <span class="hps">identified eight principle component</span>s, which will determine QOL at 67% variance. </span></li><li><span class="hps"><strong><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Conclusion</span></strong></span><strong><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">:</span></strong><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-font-weight: bold;"> </span><span class="hps"><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">According to</span></span><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> <span class="hps">the results,</span> IBS-QOL-34 <span class="hps">questionnaire</span> <span class="hps">has</span> <span class="hps">good</span> <span class="hps">psychometric</span> <span class="hps">properties</span> <span class="hps">in the research community</span> <span class="hps">and</span> <span class="hps">can be safely used as</span> <span class="hps">a</span> <span class="hps">valid</span> <span class="hps">tool</span> <span class="hps">to</span> <span class="hps">assess QOL</span> <span class="hps">of patients with</span> IBS for <span class="hps">healthcare</span> and <span class="hps">therapeutic</span> purposes.</span></li><li><span class="hps"><strong><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Keywords</span></strong></span><strong><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">:</span></strong><span style="font-size: 12.0pt; line-height: 115%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; 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mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} --> <!--[endif] -->http://jrms.mui.ac.ir/index.php/jrms/article/view/9281http://jrms.mui.ac.ir/index.php/jrms/article/download/9281/3936Journal of Research in Medical Sciences1735-199518620130709Comparative study between Ribavirin and Ribavirin plus Intravenous Immunoglobulin against Crimean Congo hemorrhagic fever497500ENDepartment of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran20130708<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> 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font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Crimean Congo hemorrhagic fever (CCHF) has high morbidity and mortality.</span></li><li><span style="mso-bidi-font-size: 14.0pt; line-height: 150%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Therefore the treatment effect of Ribavirin with and without intravenous Immunoglobulin (IVIG) in viral Crimean Congo hemorrhagic fever was evaluated.<strong> </strong></span></li><li><strong><span style="mso-bidi-font-size: 14.0pt; line-height: 150%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Materials and Methods: </span></strong><span style="mso-bidi-font-size: 14.0pt; line-height: 150%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">In a clinical trial study, 40 patients with confirmatory positive serology test, 12 (30%) received Ribavirin and IVIG (case group) and 28 (70%) received only ribavirin as standards therapy (control group). The patients were followed and compared by defervescence and other clinical symptoms, and laboratory results such as white blood cell count (WBC), platelets; liver function test (LFT) and duration of hospitalization and mortality rate after eight weeks. </span></li><li><strong><span style="mso-bidi-font-size: 14.0pt; line-height: 150%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Results: </span></strong><span style="mso-bidi-font-size: 14.0pt; line-height: 150%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">The mean (SD) period for defervescence and stopping bleedings was five (0.6) days in case group and five (0.5) days in control group with no significant differences (<em style="mso-bidi-font-style: normal;">P</em>=0.27). The mean period for return of WBC to normal was three (0.6) days in case group and five (0.8) days in control group (<em style="mso-bidi-font-style: normal;">P</em>=0.002).The mean period for return of LFT to normal was three (0.9) days in case group and seven (0.5) days in control group which showed a meaningful difference (<em style="mso-bidi-font-style: normal;">P</em>=0.001).Normalization of platelets was returned within four (0.8) days in case group compared to 6 (0.6) days in control group. Mortality was observed in three cases of each group.<strong> </strong></span></li><li><strong><span style="mso-bidi-font-size: 14.0pt; line-height: 150%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Conclusion: </span></strong><span style="mso-bidi-font-size: 14.0pt; line-height: 150%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Considering our results, using IVIG in viral hemorrhagic fever (VHF) may need further evaluations. </span></li><li><strong><span style="mso-bidi-font-size: 14.0pt; line-height: 150%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Key words: </span></strong><span style="mso-bidi-font-size: 14.0pt; line-height: 150%; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Congo fever, Hemorrhagic, IVIG, Ribavirin, Viral</span></li></ul><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 3" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 4" /> <w:LsdException Locked="false" 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mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} --> <!--[endif] -->http://jrms.mui.ac.ir/index.php/jrms/article/view/9282http://jrms.mui.ac.ir/index.php/jrms/article/download/9282/3924Journal of Research in Medical Sciences1735-199518620130709Comparison of parent adolescent scores on Strengths and Difficulties Questionnaire501505EN20130709<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> 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m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; text-justify: kashida; text-kashida: 0%; line-height: normal;"><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Background:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Child and adolescent psychiatry has benefited from the application of self-report questionnaires because it is short, less costly and easy to apply. So we select the <span style="mso-bidi-font-weight: bold;">Strengths and Difficulties Questionnaire</span> (SDQ) and evaluate the agreement between the self-report and parent report form. </span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; text-justify: kashida; text-kashida: 0%; line-height: normal;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Materials and</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> <strong>Methods:</strong> Subjects were 1934 adolescents.11-18 years old<sup> </sup>After obtaining the samples consent, SDQ parent rated form and self-rated form were filled. The collected data were analyzed using the STATA statistical package version 9. </span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; text-justify: kashida; text-kashida: 0%; line-height: normal;"><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Results:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> The adolescents obtained higher total difficulty scores than their parents, but it was not </span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: FA;">significant (<em style="mso-bidi-font-style: normal;">P</em> value = 0.203).</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Boys had higher total difficulty scores than girls by parent informant (<em style="mso-bidi-font-style: normal;">P</em> value = 0.001), but by self-report girls had higher total difficulty scores than boys (<em style="mso-bidi-font-style: normal;">P</em> value = 0.42). 11-14 years had higher total difficulty scores by parent report than self-report (<em style="mso-bidi-font-style: normal;">P</em> value = 0.42), but 15-18 years had higher total difficulty scores by self-report than parent report (<em style="mso-bidi-font-style: normal;">P</em> value = 0.36). </span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; text-justify: kashida; text-kashida: 0%; line-height: normal;"><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Conclusion:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> SDQ self-rating from adolescents may contribute better to the diagnostic process in the clinical setting<strong>.</strong></span></p> <p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; text-justify: kashida; text-kashida: 0%; line-height: normal;"><strong><span 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9283http://jrms.mui.ac.ir/index.php/jrms/article/download/9283/3925Journal of Research in Medical Sciences1735-199518620130709A transitional curriculum for preparing medical students for internship, does it work?506509ENEDO, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranEDO, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMedical Education Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, IranEDO, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranEDO, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranEDO, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranEDO, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranEDO, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran20130709<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><strong><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi;">Background<span style="text-transform: uppercase;">:</span></span></strong><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi; text-transform: uppercase;">i</span><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi;">n a formative evaluation, we were supposed to find whether an innovative program has some merits to be continued or not. We also determined the critical points of the program. The evaluated program was a clinical pre-clerkship curriculum launched for departing to a less stressful medical clerkship. </span></li><li><strong><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi;">Materials and</span></strong><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi;"> <strong>Methods<span style="text-transform: uppercase;">:</span></strong><span style="text-transform: uppercase;"> w</span>e analyzed the information contained in the students’ logbooks. Using Dundee Ready Education Environment Measure standardized questionnaire, we also assessed the students’ perception of learning environment within six clinical departments. </span></li><li><strong><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi;">Results:</span></strong><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi;"> Totally, 64% of expected patient contacts, and teaching of more than 71% of required skills at 4 departments were carried out and students had more positive than negative perspective of their learning environments. </span></li><li><strong><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi;">Conclusion:</span></strong><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi;"> The evaluand is a worthwhile program to be continued, though it needs some considerations for improvement.</span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi;">Key words: </span></strong><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: major-bidi;">Clinical skills, 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9284http://jrms.mui.ac.ir/index.php/jrms/article/download/9284/3926Journal of Research in Medical Sciences1735-199518620130709Cholorhexidine, octenidine or povidone iodine for catheter related infectıons: A randomized controlled trial510512ENDepartment of Anaesthesiology and Reanimation, Eskişehir Osmangazi University, Medical Faculty, 26100 Eskişehir, TurkeyDepartment of Anaesthesiology and Reanimation, Eskişehir Osmangazi University, Medical Faculty, 26100 Eskişehir, TurkeyDepartment of Anaesthesiology and Reanimation, Eskişehir Osmangazi University, Medical Faculty, 26100 Eskişehir, Turkey20130709<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Background:</span></strong><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Protection of the catheter site by antimicrobial agents is one of the most important factors in the prevention of infection. Povidone iodine and chlorhexidine gluconate are the most common used agents for dressing. The purpose of this study was to compare the effects of povidone iodine, chlorhexidine gluconate and octenidine hydrochloride in preventing catheter related infections. </span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Materials and Methods:</span></strong><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Patients were randomized to receive; 4% chlorhexidine gluconate, 10% povidone iodine or octenidine hydrochlorodine for cutaneous antisepsis. Cultures were taken at the site surrounding catheter insertion and at the catheter hub after removal to help identify the source of microorganisms. </span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Results<span style="text-transform: uppercase;">:</span></span></strong><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; text-transform: uppercase;"> c</span><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">atheter related sepsis was 10.5% in the povidone iodine and octenidine hydrochlorodine groups. Catheter related colonization was 26.3% in povidone iodine group and 21.5% in octenidine hydrochlorodine group. </span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Conclusion:</span></strong><span style="font-size: 12.0pt; mso-bidi-font-size: 11.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> 4% chlorhexidine or octenidine hydrochlorodine for cuetaneous disinfection before insertion of an intravascular device and for post-insertion site care can reduce the catheter related colonization.</span></li><li><strong 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mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">, </span></span><span class="hps"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">physical</span></span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> <span class="hps">and</span> <span class="hps">psychic</span> <span class="hps">traumas of</span> <span class="hps">eye may be responsible for development of</span> <span class="hps">strabismus</span></span><span class="gt-trans-draggable"><span style="font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">. </span></span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Anemia may cause sensory-neural disorders in children. We investigated t<span class="hps"><span style="mso-bidi-font-weight: bold;">he relationship between</span></span><span style="mso-bidi-font-weight: bold;"> <span class="hps">anemia</span> <span class="hps">and</span> <span class="hps">accommodative esotropia in children. </span></span></span></li><li><span class="hps"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Materials</span></strong></span><span class="hps"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> <strong style="mso-bidi-font-weight: normal;">and</strong> <strong style="mso-bidi-font-weight: normal;">Methods:</strong> Sixty-four patients with </span></span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">accommodative esotropia were evaluated. This group was identified as patient group (group 1). <span class="hps">Eighty-</span>three pediatric patients, who were not esotropia and only had <span class="hps">refraction problems</span>, were identified as control group (group 2). The difference between the groups was statistically analyzed evaluating patients for anemia. </span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Results:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> 33 of 64 patients with accommodative esotropia in group 1 were male, as 43 of 83 patients with refractive error in group 2 were male. The mean age of patients in group 1 and 2 were 6 ± 3.92 and 6.37 ± 2.74 (<em style="mso-bidi-font-style: normal;">P</em> > 0.05) respectively. There was significant difference between two groups, when mean hemoglobin value of those was compared (<em style="mso-bidi-font-style: normal;">P</em> < 0.05). </span></li><li><strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Conclusion:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Hb level may affects the accommodative esotropia.</span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-fareast-language: TR;">Key</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-fareast-language: TR;"> <strong style="mso-bidi-font-weight: normal;">words:</strong> Anemia, </span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">child, esotropia, strabismus</span></li></ul><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9286http://jrms.mui.ac.ir/index.php/jrms/article/download/9286/3928Journal of Research in Medical Sciences1735-199518620130709Medical publication and scientometrics516521ENDepartment of Family Medicine, University of Sarajevo, Bosnia and Herzegovina20130709<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">As the fact that today is conducted a number of scientific research works in the field of medicine, it is necessary to define the steps by which it is carried out to make it universal and to have scientific value. This paper describes the research methods, study design, the way in which one should be written, and why it is important to publicize the same. Special emphasis is placed on scientometrics as the science that evaluates scientific papers and their citation in the selected sample of journals. 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9287http://jrms.mui.ac.ir/index.php/jrms/article/download/9287/3929Journal of Research in Medical Sciences1735-199518620130709Laparoscopic phrenectomy for a diaphragmatic neurilemmoma522525ENDepartments of Hepatobiliary Surgery and Ultrasound, Qingdao, Municipal Hospital, Ocean University of China, Qingdao, ChinaUltrasound, Qingdao, Municipal Hospital, Ocean University of China, Qingdao, ChinaDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China20130709<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Diaphragmatic neurilemmoma (schwannoma) is an extremely rare tumor that is often discovered incidentally. Even when diagnosed, patients are commonly advised only to attend regular follow-up appointments as conventional tumorectomy is enormously invasive and confers relatively few benefits. Here, we report a unique case of a diaphragmatic neurilemmoma with concomitant symptomatic cholecystolithiasis, who was treated successfully by pure laparoscopy. The entire operation lasted 65 min, and patient was discharged uneventfully on the 3<sup>rd</sup> post-operative day. The follow-up for 29 months has shown with no recurrence or symptoms.</span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Key words:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> Diaphragmatic neurilemmoma, diaphragmatic tumor, laparoscopy</span></li></ul><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="9" 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A 50-year-old woman presented with a 2-year history of neck pain and ataxia for 1 year. She had not urinary incontinence. She was referred to a neurosurgeon by a neurologist because of her progressive gait ataxia</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">.</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: AR-SA;"> Risk for brachial plexus injury because of compression or stretching by the clavicle accelerate with age. </span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Therefore, the surgical approach of adults’ patients with Sprengel’s deformity </span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: AR-SA;">can intend suitable</span><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> surgical conclusions.</span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: AR-SA;">Key words:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi; mso-bidi-language: AR-SA;"> Cervical myelopathy, Klippel-Feil syndrome, omovertebral bone, sprengel deformity</span></li></ul><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> <w:LsdException Locked="false" Priority="0" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="Normal" /> <w:LsdException Locked="false" Priority="9" SemiHidden="false" UnhideWhenUsed="false" QFormat="true" Name="heading 1" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 2" /> <w:LsdException Locked="false" Priority="9" QFormat="true" Name="heading 3" /> <w:LsdException Locked="false" Priority="9" QFormat="true" 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9289http://jrms.mui.ac.ir/index.php/jrms/article/download/9289/3930Journal of Research in Medical Sciences1735-199518620130709Orbital solitary fibrous tumor: A rare clinicopathologic correlation and review of literature529531ENDepartment of Ocular Oncology Service, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, Andhra Pradesh, IndiaDepartment of Ocular Oncology Service, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, Andhra Pradesh, IndiaDepartment of Ocular Oncology Service, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, Andhra Pradesh, IndiaDepartment of Ocular Oncology Service, L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, Andhra Pradesh, India20130709<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:DoNotShowRevisions /> <w:DoNotPrintRevisions /> <w:DoNotShowInsertionsAndDeletions /> <w:DoNotShowPropertyChanges /> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>EN-US</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>AR-SA</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> <w:SplitPgBreakAndParaMark /> <w:DontVertAlignCellWithSp /> <w:DontBreakConstrainedForcedTables /> <w:DontVertAlignInTxbx /> <w:Word11KerningPairs /> <w:CachedColBalance /> </w:Compatibility> <m:mathPr> <m:mathFont m:val="Cambria Math" /> <m:brkBin m:val="before" /> <m:brkBinSub m:val=" " /> <m:smallFrac m:val="off" /> <m:dispDef /> <m:lMargin m:val="0" /> <m:rMargin m:val="0" /> <m:defJc m:val="centerGroup" /> <m:wrapIndent m:val="1440" /> <m:intLim m:val="subSup" /> <m:naryLim m:val="undOvr" /> </m:mathPr></w:WordDocument> </xml><![endif]--><ul><li><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Orbital solitary fibrous tumor (SFT) is a rare tumor and orbits are a very uncommon site. It is mostly noted to arise from mesenchymal structures like pleura and peritoneum. The diagnosis of orbital SFT cannot be made with certainty on clinical or radiological evaluation alone and requires immunohistochemical studies for confirmation. Orbital SFT’s usually show an indolent clinical course and a complete cure can usually be achieved with complete resection. We describe clinical presentations, radiological and operative findings, and pathological features of a patient with orbital SFT along with a review of literature.</span></li><li><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;">Key words:</span></strong><span style="font-size: 12.0pt; font-family: "Times New Roman","serif"; mso-ascii-theme-font: major-bidi; mso-fareast-font-family: Calibri; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: major-bidi;"> BCL-2, CD34, hemangiopericytoma, solitary fibrous tumor, orbit</span></li></ul><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true" DefSemiHidden="true" DefQFormat="false" DefPriority="99" LatentStyleCount="267"> 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</style> <![endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/9290http://jrms.mui.ac.ir/index.php/jrms/article/download/9290/3934Journal of Research in Medical Sciences1735-199518620130709The healing effect of licorice (Glycyrrhiza glabra) on Helicobacter pylori infected peptic ulcers532533ENDepartment of Pharmacology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pathology, Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Internal Medicine, Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Internal Medicine, Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran20130709-http://jrms.mui.ac.ir/index.php/jrms/article/view/9291http://jrms.mui.ac.ir/index.php/jrms/article/download/9291/3935Journal of Research in Medical Sciences1735-199518620130709Analysis of serum peptidome patterns of patients stung by honey bees534535ENNephrology Department of the 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Central Laboratory, Guilin, ChinaNephrology Department of the 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Central Laboratory, Guilin, ChinaNephrology Department of the 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Central Laboratory, Guilin, ChinaNephrology Department of the 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Central Laboratory, Guilin, China20130709-http://jrms.mui.ac.ir/index.php/jrms/article/view/9292http://jrms.mui.ac.ir/index.php/jrms/article/download/9292/3933Journal of Research in Medical Sciences1735-199518620130709Diabetic retinopathy and vascular endothelial growth factor92939293ENDepartment of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran20130709-http://jrms.mui.ac.ir/index.php/jrms/article/view/9293http://jrms.mui.ac.ir/index.php/jrms/article/download/9293/3932