The influence of calcium supplement on body composition, weight loss and insulin resistance in obese adults receiving low calorie diet

Journal of Research in Medical Sciences1735-199515420100525The influence of calcium supplement on body composition, weight loss and insulin resistance in obese adults receiving low calorie diet191201ENIran university of Medical scienceIran university of Medical ScienceIran university of Medical ScienceIran university of Medical ScienceIran university of Medical Science2009080120100314  <ul style="margin-top: 0cm;" type="disc"><li class="MsoNormal">BACKGROUND: Obesity and diabetes are the most important problems of public health. Evidence from molecular animal research and epidemiologic investigations indicate that calcium intake may have an influence on body composition, weight and insulin resistance. The objective of this study was to determine the effects of calcium supplementation on body composition, weight, insulin resistance and blood pressure in the face of calorie restriction in obese adults.</li><li class="MsoNormal">METHODS: A double blind randomized placebo-controlled trial on 40 adults with Body Mass Index > 25kg/m² was conducted. Subjects were maintained for 24 weeks on a balanced deficit diet (-500 kcal/d deficit) and randomly assigned into two groups with 1000 mg ca/d as calcium carbonate or placebo.</li><li class="MsoNormal">RESULTS: There were no significant differences in variables at the 12th and 24th week between the two groups. The lean mass showed no significant increase in the calcium group at the 12th week compared to baseline and in placebo group at the 24th week compared to the 12th week. The insulin concentration showed a significant decrease in the calcium group at the 12th week compared to the baseline (p < 0.05). The diastolic blood pressure had a significant decrease at the 24th week compared to the 12th week in both groups (p = 0.013-0.009).</li><li class="MsoNormal">CONCLUSIONS: Results from this study suggest that 24 weeks of supplementation with 1000 mg ca/d did not have any effect on weight, body composition, insulin resistance and blood pressure beyond what can be achieved in an energy restricted diet in obese adults.</li><li class="MsoNormal">KEYWORDS: Calcium Supplement, Insulin Resistance, Body Composition, Obesity, Weight Loss.</li></ul>  http://jrms.mui.ac.ir/index.php/jrms/article/view/4067http://jrms.mui.ac.ir/index.php/jrms/article/download/4067/2097

Journal of Research in Medical Sciences1735-199515420100525Activity of daily living and its associated factors in war survivors with no visual acuity202207ENJanbazan Medical and Engineering Research Center, Tehran, IranStatistics Department, School of Management and Medical Information & Health Sciences, Iran University of Medical Sciences, Tehran, IranJanbazan Medical and Engineering Research Center, Tehran, IranJanbazan Medical and Engineering Research Center, Tehran, Iran2009091820100406 <ul><li>BACKGROUND: War is a known cause of tremendous physical injuries to different body organs, and eyes are not exceptions. War-related no visual acuity (NVA) affects both the victim and the family. Activity of daily living (ADL) can display personal life independency and is considered as a morbidity index. This study was designed to investigate the ADL profile of war survivors with NVA.</li><li>METHODS: This cross-sectional study was conducted in 2007 in Iran. In this study, 500 Iranian people with war related NVA were invited to take part in a camp in Mashhad city.  ADL was evaluated using Barthel Index and demographic data were collected using a data sheet. Stepwise linear regression was used to determine the associates of ADL.</li><li>RESULTS: The overall response rate to the invitation was 50%. From the total 250 participants 96.5% were male with a mean age of 43 ± 8 years. Only 8.3% had no dependency in ADL and other 91.7% had some ranges of dependency in at least one of the daily living activities. ADL score was higher in highly educated participants, those younger than 50 years old, those with less co-morbid physical problems (hearing loss) and those with regular physical exercises. According to regression analysis, age and duration of war related NVA were significant predictors of ADL.</li><li>CONCLUSIONS: According to the results, both age and the time passed from war related NVA increase the dependency of people with war related NVA.</li><li>KEYWORDS: War, No Visual Acuity, Activity of Daily Living.</li></ul>  http://jrms.mui.ac.ir/index.php/jrms/article/view/4230http://jrms.mui.ac.ir/index.php/jrms/article/download/4230/2122

Journal of Research in Medical Sciences1735-199515420100525Comparison of divided sciatic nerve growth within dermis, venous and nerve graft conduit in rat208213ENAssociate Professor of Plastic and Reconstructive Surgery, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.Associate Professor of Plastic and Reconstructive Surgery, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.Associate Professor of Plastic and Reconstructive Surgery, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.Plastic and Reconstructive Surgeon, Qom University of Medical Sciences, Qom, IranAssistant Professor of Plastic and Reconstructive Surgery, Ghazvin University of Medical Sciences, Ghazvin, Iran.Veterinary Surgeon, Department of Clinical Sciences, Veterinary Fatuity, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.Physician, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, IranAssistant Professor of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran.Resident of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran2009093020100208<ul><li>BACKGROUND: Considering the common origin of skin and peripheral nervous system, a tube of dermal layer of skin hypothetically can be an ideal conduit for nerve reconstruction. An experimental study performed to evaluate the nerve regeneration of efficacy into a dermal tube.</li><li>METHODS: Sixty male Wistar rats were used. A 10 mm gap was produced in right sciatic nerves. In group A the autogenous nerve grafts were used to bridge the defects. In group B vein conduit were use to reconstruct the gaps. In group C dermal tube were used to bridge the defects. Morphologic studies were carried out after 3 month.</li><li>RESULTS: The density of nerve fibers was significantly higher in autogenous nerve graft group. The efficacy of nerve growth into the dermal tube group was significantly poor in comparison to other groups.</li><li>CONCLUSIONS: In the present study, dermis was used as the nerve conduit for the first time. This study indicates that the dermal tube is not a suitable conduit for nerve regeneration till further studies to resolve the problems before clinical application.</li><li>KEYWORDS: Nerve Injury, Nerve Gap, Nerve Conduit, Dermal Tube, Autogenous Nerve Graft.</li></ul> http://jrms.mui.ac.ir/index.php/jrms/article/view/4279http://jrms.mui.ac.ir/index.php/jrms/article/download/4279/1987

Journal of Research in Medical Sciences1735-199515420100525A comparison of the effect of intranasal desmopressin and intramuscular hyoscine N-butyl bromide combination with intramuscular hyoscine N-butyl bromide alone in acute renal colic214218ENUrology Department, Shohadaye-Ashayer Hospital, Lorestan University of Medical Sciences, Khorram Abad, Iran.Urology Department, Shohadaye-Ashayer Hospital, Lorestan University of Medical Sciences, Khorram Abad, Iran.Urology Department, Shohadaye-Ashayer Hospital, Lorestan University of Medical Sciences, Khorram Abad, Iran.200910242010042520100210<ul><li>BACKGROUND: Patients with acute renal colic usually require immediate diagnosis and treatment. In this clinical trial analgesic effect of hyoscine N-butyl bromide and desmopressin combination in comparison with hyoscine N-butyl bromide alone in patients with acute renal colic induced by urinary stones was assessed.</li><li>METHODS: The study included 114 patients randomly allocated in two groups (A and B). Patients in group A received 20 mg intramuscular hyoscine N-butyl bromide at admission time and patients in group B received 20 µg of intranasal desmopressin in combination with 20 mg intramuscular hyoscine N-butyl bromide. A visual analogue scale (VAS; a 10-cm horizontal scale ranging from "zero or no pain" to "10 or unbearable pain") was hired to assess the patients' pain severity at baseline, 30 and 60 minutes after the treatments.</li><li>RESULTS: On admission, the pain level was similar in both groups (group A: 8.95 ± 0.11 and group B: 8.95 ± 0.12). In group A, the mean of pain level showed a decrease after 30 minutes  (group A: 7.26 ± 0.25 and group B: 5.95 ± 0.28) but further decreasing did not occur; however in group B, the pain consistently decreased and the mean after 60 minutes was significantly decreased (group A: 6.80 ± 0.31 and group B: 3.71 ± 0.31). No side effects were detected in this study.</li><li>CONCLUSIONS: The combination of hyoscine N-butyl bromide and desmopressin is more effective than hyoscine N-butyl bromide alone in patients with renal colic. Further studies are recommended to validate these findings and compare the different doses of desmopressin.</li><li>KEYWORDS: Calculus, Renal Colic, Analgesia, Desmopressin.</li></ul>http://jrms.mui.ac.ir/index.php/jrms/article/view/4403http://jrms.mui.ac.ir/index.php/jrms/article/download/4403/2110

Journal of Research in Medical Sciences1735-199515420100525The design and equipments of hospital pharmacies in Isfahan, Iran219224ENIUMSResident of Clinical Pharmacy, Department of Pharmacotherapy, Tehran University of Medical Sciences, Tehran, IranDepartment of Research and Development, Vice-Chancellery for Administration and Financial Affairs, Isfahan University of Medical Sciences, Isfahan, IranPharmacy Student, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences Isfahan, Iran.2009111020100312 <ul><li>BACKGROUND: Nowadays pharmaceutical care departments located in hospitals are amongst the important pillars of the healthcare system. The aim of this study was to evaluate designing features and equipments of hospital drugstores affiliated with Isfahan University of Medical Sciences.</li><li>METHODS: In this cross-sectional study a self-defined and validated questionnaire was used which included all the necessary and standard needed spaces and equipments of an ideal hospital pharmacy. The questionnaire was filled in by one of the researchers in all twelve hospital drugstores located in the teaching and non-teaching hospitals affiliated with Isfahan University of Medical Sciences. Data analysis was done using SPSS (version 14).</li><li>RESULTS: Results showed that 56% of drugstore space allocations were unsuitable. Used pharmaceutical equipments in 75% of surveyed hospitals were not according to the standards. Almost all of these pharmacies had rather an enough space for storage, but cold storages were not designed in 58% of them. In 66% of perused hospitals, pharmaceutical services disposal level was admissible. The structural engineering parameters like size and dimensions, available spaces, availability of structural planes, existence of air conditioning systems and brightness controllers, adequate stores for drugs and safe places for narcotics were observed in 55% of pharmacies.</li><li>CONCLUSIONS: There are apparent out of standard space allocations and shortages of needed equipments for offering drug services in studied drugstores that may probably lead to a waste of time and money. These issues may reduce the efficiency and safety of pharmaceutical services and drug administration in hospitals.</li><li>KEYWORDS: Hospital Pharmacy, Pharmacy Management, Pharmacy Design, Isfahan.</li></ul> http://jrms.mui.ac.ir/index.php/jrms/article/view/4495http://jrms.mui.ac.ir/index.php/jrms/article/download/4495/2088

Journal of Research in Medical Sciences1735-199515420100525Enhancement of the efficacy of cancer chemotherapy by the pineal hormone melatonin and its relation with the psychospiritual status of cancer patients225228ENPsychological Service, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, ItalyInstitute of Biological Medicine, MilanNatur Spiritual, MilanPsychological Division,Bassini Hospital, Cinisello, MilanSurgery Division,Bassini Hospital, Cinisello, MilanFoundation Legrenzi-Cazzullo, Milan2009120420100131<ul><li>BACKGROUND: The anti-oxidant and immunomodulating natural agents may enhance the efficacy of cancer chemotherapy. One of the most important agents is the pineal hormone melatonin (MLT) which may exert both anti-oxidant and antiproliferative immunostimulating anticancer effects. This study was performed to evaluate the efficacy of a biochemotherapeutic regimen in metastatic cancer patients, and its therapeutic activity in relation to the psychospiritual status of patients.</li><li>METHODS: The study included 50 metastatic non-small cell lung cancer (NSCLC) patients and a control group of 100 patients. Chemotherapy consisted of cisplatin plus gemcitabine. MLT was given orally at 20 mg/day in the evening. Patients were subdivided into 5 psychic profiles, as follows: spiritual faith, rationale faith, anxiety, apathy, and accusation behavior.</li><li>RESULTS: Tumor response rate was significantly higher in patients treated by chemotherapy plus MLT than in those treated by chemotherapy alone (21/50 vs. 24/100, p < 0.001). However, the percentage of objective tumor regressions obtained in patients with spiritual faith was significantly higher than that found in the overall other patients concomitantly treated by chemotherapy plus MLT (6/8 vs. 15/42, p < 0.01).</li><li>CONCLUSIONS: In conclusion, the efficacy of chemotherapy may be enhanced by the pineal hormone MLT, by representing a new promising biochemotherapeutic combination; also despite its objective ability to enhance chemotherapy efficacy, the activity of MLT is depending at least in part on the psychospiritual status of cancer patients, and it is maximal in the presence of a real spiritual faith.</li><li>KEYWORDS: Bioimmunomodulation, Chemotherapy, Lung Cancer, Melatonin, Psychoncology, Spirituality.</li></ul>  http://jrms.mui.ac.ir/index.php/jrms/article/view/4583http://jrms.mui.ac.ir/index.php/jrms/article/download/4583/2089

Journal of Research in Medical Sciences1735-199515420100525Bipolar Disorder Patients Follow-up (BDPF): methods and materials229234ENMental Health Research CentreTehran Psychiatric Institute, Iran University of Medical Sciences and Health Services, Tehran, IranTehran Psychiatric Institute, Iran University of Medical Sciences and Health Services, Tehran, IranTehran Psychiatric Institute, Iran University of Medical Sciences and Health Services, Tehran, IranTabriz University of Medical Sciences and Health Services, Tabriz, IranIran Hospital of Psychiatry, Iran University of Medical Sciences and Health Services, Tehran, IranBipolar Disorders Research Group, Mental Health Research Centre, Iran University of Medical Sciences and Health Services, Tehran, IranBipolar Disorders Research Group, Mental Health Research Centre, Iran University of Medical Sciences and Health Services, Tehran, IranTehran Psychiatric Institute, Iran University of Medical Sciences and Health Services, Tehran, IranTehran Psychiatric Institute, Iran University of Medical Sciences and Health Services, Tehran, IranIran Hospital of Psychiatry, Iran University of Medical Sciences and Health Services, Tehran, IranIran Hospital of Psychiatry, Iran University of Medical Sciences and Health Services, Tehran, IranBipolar Disorders Research Group, Mental Health Research Centre, Iran University of Medical Sciences and Health Services, Tehran, IranBipolar Disorders Research Group, Mental Health Research Centre, Iran University of Medical Sciences and Health Services, Tehran, Iran200912162010013120100117<ul><li>BACKGROUND: The Bipolar Disorder Patients Follow-up (BDPF) project is a longitudinal, prospective and naturalistic study. The purpose of the present report is to introduce the project, elaborate its methods, and present the reliability data of the utilized symptoms rating scales.</li><li>METHODS: The sampling started in May 2008 and is still in progress. The probands are assessed at the beginning of the sampling and then 2 and 6 months later and then every 6 months using several instruments to identify psychiatric comorbidities, symptoms severity, quality of life, attempted suicide rate, treatment compliance, and some other factors.</li><li>RESULTS: The results could lead to increase the clinicians' awareness about the clinical picture of this disorder in Iranian patients.</li><li>CONCLUSIONS: The present project could decrease to some extent the current shortcomings in Iran's psychiatric data at least about one of the major psychiatric disorders known as the eighth result which cause medical disability over the world.</li><li>KEYWORDS: Bipolar Disorder, Follow Up, Naturalistic Study, Outcome Study, Longitudinal Study, Iran.</li></ul> http://jrms.mui.ac.ir/index.php/jrms/article/view/4616http://jrms.mui.ac.ir/index.php/jrms/article/download/4616/1986

Journal of Research in Medical Sciences1735-199515420100525Characteristic and follow-up of subglottic hemangiomas in Iranian children235239ENAssistant Professor of Pediatrics, Pediatric Pulmonology Fellow, Mofid Children Hospital, Shahid Beheshti Medical University, Tehran, Iran.Assistant Professor of Pediatrics, Pediatric Pulmonology Fellow, Mofid Children Hospital, Shahid Beheshti Medical University, Tehran, Iran.Assistant Professor of Radiology, Mofid Children Hospital, Shahid Beheshti Medical University, Tehran, IranAssistant Professor of Radiology, Mofid Children Hospital, Shahid Beheshti Medical University, Tehran, Iran200909112010042520100515<ul><li>Subglottic hemangiomas are very rare in compare with cutaneous form but can be life-threatening in the proliferating phase of tumor by airway obstruction. It should be considered in any child with recurrent, persistent and/or progressive, inspiratory or biphasic stridor, respiratory distress and feeding difficulties in the first months of life. It should be confirmed by endobronchoscopic evaluation. Affected infants are most likely to experience symptoms between the ages of 6 and 12 weeks. Infants who admitted and referred to our hospital with recurrent stridor, cough and respiratory distress were reviewed.</li><li>KEYWORDS: Subglotic Hemangioma, Laser Therapy, Tracheostomy, Respiratory Distress, Recurrent Stridor.</li></ul> http://jrms.mui.ac.ir/index.php/jrms/article/view/4217http://jrms.mui.ac.ir/index.php/jrms/article/download/4217/2121

Journal of Research in Medical Sciences1735-199515420100525Granulosa cell tumor in a six-year-old girl presented as precocious puberty240242ENPediatric Endocrinologist, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, IranPediatric Endocrinologist, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iranb Associate Professor of Pediatric Surgery, Department of Pediatric Surgery, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor of Pathology, Department of Pathology, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sci-ences, Isfahan, Iran.Pediatrician, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.200909272010022220100124   <ul type="disc"><li class="MsoNormal">Ovarian sex cord-stromal tumors, including granulose cell tumors (GCTs), are a group of neoplasms that occur rarely, especially in children. Only 0.1 percent of all ovarian tumors and 4-5 percent of GCTs occur in children. The most common presentation of these tumors in children is precocious puberty. We report a 6 years old girl with isosexual precocity, presented as premature thelarche and vaginal bleeding. Ultrasonography of pelvis showed a ypoechoic solid mass of left ovary.Microscopic features of the resected mass were characteristic of juvenile GCT. Although in most of girls with precocious puberty, the etiology is idiopathic, important causes, such as ovarian tumors must be considered.</li><li class="MsoNormal">KEYWORDS: Granulosa Cell Tumor, Puberty, Children.</li></ul>  http://jrms.mui.ac.ir/index.php/jrms/article/view/4270http://jrms.mui.ac.ir/index.php/jrms/article/download/4270/2074

Journal of Research in Medical Sciences1735-199515420100525Evaluation of the Serum Level of Herpes Simplex Type 2 Antibody among Pregnant Women in Shahid Beheshti Hospital, Isfahan44434443ENdepartment of Obstetrics and Gynecology, school of medicinedepartment of Obstetrics and Gynecology, school of medicine: Department of Bacteriology and Virology, Faculty of Medicinegeneral practitioner, school of medicinegeneral practitioner, school of medicine2009110220100411http://jrms.mui.ac.ir/index.php/jrms/article/view/4443http://jrms.mui.ac.ir/index.php/jrms/article/download/4443/2095