A comparison of the effect of intranasal desmopressin and intramuscular hyoscine N-butyl bromide combination with intramuscular hyoscine N-butyl bromide alone in acute renal colic

Journal of Research in Medical Sciences1735-199515420100525A comparison of the effect of intranasal desmopressin and intramuscular hyoscine N-butyl bromide combination with intramuscular hyoscine N-butyl bromide alone in acute renal colic214218ENUrology Department, Shohadaye-Ashayer Hospital, Lorestan University of Medical Sciences, Khorram Abad, Iran.Urology Department, Shohadaye-Ashayer Hospital, Lorestan University of Medical Sciences, Khorram Abad, Iran.Urology Department, Shohadaye-Ashayer Hospital, Lorestan University of Medical Sciences, Khorram Abad, Iran.200910242010042520100210<ul><li>BACKGROUND: Patients with acute renal colic usually require immediate diagnosis and treatment. In this clinical trial analgesic effect of hyoscine N-butyl bromide and desmopressin combination in comparison with hyoscine N-butyl bromide alone in patients with acute renal colic induced by urinary stones was assessed.</li><li>METHODS: The study included 114 patients randomly allocated in two groups (A and B). Patients in group A received 20 mg intramuscular hyoscine N-butyl bromide at admission time and patients in group B received 20 µg of intranasal desmopressin in combination with 20 mg intramuscular hyoscine N-butyl bromide. A visual analogue scale (VAS; a 10-cm horizontal scale ranging from "zero or no pain" to "10 or unbearable pain") was hired to assess the patients' pain severity at baseline, 30 and 60 minutes after the treatments.</li><li>RESULTS: On admission, the pain level was similar in both groups (group A: 8.95 ± 0.11 and group B: 8.95 ± 0.12). In group A, the mean of pain level showed a decrease after 30 minutes  (group A: 7.26 ± 0.25 and group B: 5.95 ± 0.28) but further decreasing did not occur; however in group B, the pain consistently decreased and the mean after 60 minutes was significantly decreased (group A: 6.80 ± 0.31 and group B: 3.71 ± 0.31). No side effects were detected in this study.</li><li>CONCLUSIONS: The combination of hyoscine N-butyl bromide and desmopressin is more effective than hyoscine N-butyl bromide alone in patients with renal colic. Further studies are recommended to validate these findings and compare the different doses of desmopressin.</li><li>KEYWORDS: Calculus, Renal Colic, Analgesia, Desmopressin.</li></ul>http://jrms.mui.ac.ir/index.php/jrms/article/view/4403http://jrms.mui.ac.ir/index.php/jrms/article/download/4403/2110