Comparison of divided sciatic nerve growth within dermis, venous and nerve graft conduit in rat

Journal of Research in Medical Sciences1735-199515420100525Comparison of divided sciatic nerve growth within dermis, venous and nerve graft conduit in rat208213ENAssociate Professor of Plastic and Reconstructive Surgery, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.Associate Professor of Plastic and Reconstructive Surgery, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.Associate Professor of Plastic and Reconstructive Surgery, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.Plastic and Reconstructive Surgeon, Qom University of Medical Sciences, Qom, IranAssistant Professor of Plastic and Reconstructive Surgery, Ghazvin University of Medical Sciences, Ghazvin, Iran.Veterinary Surgeon, Department of Clinical Sciences, Veterinary Fatuity, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.Physician, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, IranAssistant Professor of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran.Resident of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran2009093020100208<ul><li>BACKGROUND: Considering the common origin of skin and peripheral nervous system, a tube of dermal layer of skin hypothetically can be an ideal conduit for nerve reconstruction. An experimental study performed to evaluate the nerve regeneration of efficacy into a dermal tube.</li><li>METHODS: Sixty male Wistar rats were used. A 10 mm gap was produced in right sciatic nerves. In group A the autogenous nerve grafts were used to bridge the defects. In group B vein conduit were use to reconstruct the gaps. In group C dermal tube were used to bridge the defects. Morphologic studies were carried out after 3 month.</li><li>RESULTS: The density of nerve fibers was significantly higher in autogenous nerve graft group. The efficacy of nerve growth into the dermal tube group was significantly poor in comparison to other groups.</li><li>CONCLUSIONS: In the present study, dermis was used as the nerve conduit for the first time. This study indicates that the dermal tube is not a suitable conduit for nerve regeneration till further studies to resolve the problems before clinical application.</li><li>KEYWORDS: Nerve Injury, Nerve Gap, Nerve Conduit, Dermal Tube, Autogenous Nerve Graft.</li></ul> http://jrms.mui.ac.ir/index.php/jrms/article/view/4279http://jrms.mui.ac.ir/index.php/jrms/article/download/4279/1987