Journal of Research in Medical Sciences1735-199515320100222172174ENDepartment of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranNeurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Physiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Physiology, Pasteur Institute of Iran, Tehran, Iran.Department of Anatomy and Histology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran2009092320100105<ul><li><strong><span style="font-size: 8pt;">BACKGROUND:</span></strong> <span class="abstractChar">The present study evaluated the effects of treadmill running on extracellular basal levels of glutamate and GABA at dentate gyrus of streptozotocin-induced diabetic rats.</span></li><li><strong><span style="font-size: 8pt;">METHODS:</span></strong><strong><span style="font-size: 8pt;"> </span></strong><span class="abstractChar">After 12 weeks of diabetes induction and exercise period, extracellular levels of glutamate and GABA were investigated.</span></li><li><strong><span style="font-size: 8pt;">RESULTS:</span></strong><span class="abstractChar"> The results showed that glutamate levels were significantly decreased in diabetes-rest group comparing to the control-rest and the diabetes-exercise groups.</span></li><li><strong><span style="font-size: 8pt;">CONCLUSIONS:</span></strong><span class="abstractChar"> The findings support the possibility that treadmill running is helpful in alleviating neurotransmitter homeostasis and alterations in transmission in diabetes mellitus.</span></li><li><strong><span style="font-size: 8pt;">KEYWORDS: </span></strong><span class="abstractChar">Diabetes, Glutamate, GABA, Dentate Gyrus, Treadmill Running, Microdialysis, Hippocampus, Streptozotocin</span>.</li></ul><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> <w:UseAsianBreakRules /> <w:DontGrowAutofit /> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> </w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" LatentStyleCount="156"> </w:LatentStyles> </xml><![endif]--> <!--[endif]-->http://jrms.mui.ac.ir/index.php/jrms/article/view/4254http://jrms.mui.ac.ir/index.php/jrms/article/download/4254/1962