Journal of Research in Medical Sciences1735-1995642001120134493449ENAnesthesiology Department, School of Medicine, Isfaban University of Medical Sciences and Health Services,Isfahan, Iran2001120120090411Introduction: In this study amnesic and anesthetic effects of Midazolam used to reduce awarness and recall of neurolept Anesthesia. Methods: The study was clinical trial with simple random sampling. Patients were studied in four groups of 30 numbers. Each preparation and induction of anesthesia was identical in all groups. Bolous Thiopental (BT) group received 0.3mg/kg NaThiopental during induction of Anesthesia. Infusion thiopental group (IT) 0.3mg/kg Na thiopental was given during induction plus 100mg/kg/min for Maintaince of anesthesia. Bolous Midazolam (BM) group recieved 0.1 mg/kg Midazolam during induction and Infusion Midazolam (lM) groug 0.1 mg/kg during Induction plus 0.1mg/kg/h for maintainance of Anesthesia. All groups were observed for signs of awareness and recall. Also hemodynamic variables and duration of recovery were measured and compared between groups with analysis of variance and Chi square tests. Result: Signs of Awareness (tachycardia and Lacrimation) in IM group was significantly less than other groups. (P<0.05) Percent of patients reported recall were significantly lower in IM group. (P<0.05) Discussion: Infusion of Midazolam can reduce signs of awareness and recall during neurolept anesthesia without increase in complications or duration of recovery periodhttp://jrms.mui.ac.ir/index.php/jrms/article/view/3449