Journal of Research in Medical Sciences1735-1995632001090134103410ENEndocrine and Metabolic Research Center, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran2001090120090411Introduction. In this study we wanted to compare the means of area under the curve (AVC) of glucose tolerance test in young women depending on dehydroepiandrosteron (DHEA) levels. Methods. Selected subjects were examined for DHEA and glucose tolerance test. At first, they were divided into two groups (under the mean of DHEA vs above the mean of DHEA) and then into three groups (under the mean-SD, between the mean±SD, above the mean + SD). 37 young women with no abnormality whose 8MI was below 30 Kg/m2 they were refered to research center of endocrinology and metabolism of IUMSHS. Results. The mean of DHEA was 2895±1113 ng/ml. The mean of AUC was 745±104.7 mmol/l/min in women under the mean of DHEA and 670±51.9 mmol/l/min in women above the mean of DHEA (P < 0.05). In comparison of women based on mean±SD, the AVe was 786±88.3, 691. 7 ± 77.5 and 670.8±92.5 mmol/l/min, respectively. Results showed a significant decrease of AVC in women above the mean+ SO of DHEA (P < 0.05). Discussion. This study suggests that in young healthy women DHEA can increase the glucose tolerance.http://jrms.mui.ac.ir/index.php/jrms/article/view/3410