Journal of Research in Medical Sciences1735-19952946202410151158411584EN20241015<p><strong>Background:</strong> This study investigated the effects of humor therapy on the fatigue levels of patients receiving hemodialysis (HD).</p><p><strong>Materials and Methods:</strong> A single?blind, randomized clinical trial of 66 HD patients for 3 weeks was conducted, in which two groups were randomly allocated – humor therapy and control. In the intervention group, humor therapy sessions were conducted twice a<br />week for 3 weeks. As a pre? and postintervention assessment, the Fatigue Symptom Inventory (FSI) was completed.</p><p><strong>Results:</strong> According to the repeated?measures ANOVA test, FSI values exhibited a  significant decline in the humor therapy group and an increase in the control group at the first, second, and third visits (humor therapy vs. control: 30.38 ± 8.75 and 61.80 ± 13.92, P &lt; 0.001; 35.71 ± 10.05 and 69.53 ± 15.32, P &lt; 0.001; and 34.85 ± 9.24 and 70.34 ± 22.26, P &lt; 0.001, respectively) compared with baseline (humor therapy vs.</p><p><strong>control:</strong> 49.26 ± 5.19 and 52.09 ± 11.69, P = 0.204). Conclusion: Findings suggest that humor therapy can effectively reduce fatigue levels in patients presenting with HD.<br /><br /></p>http://jrms.mui.ac.ir/index.php/jrms/article/view/11584http://jrms.mui.ac.ir/index.php/jrms/article/download/11584/6362