Journal of Research in Medical Sciences1735-1995238201808251082210822EN20180820<span class="fontstyle0">Background: </span><span class="fontstyle2">Diabetes is associated with oxidative stress and considered as a major risk factor for cardiac disease. We attempted to investigate the role of oral antidiabetic (OAD) agents gliclazide and metformin in lowering the lipid peroxidation and managing the risk for cardiovascular (CV) complications in diabetic patients in comparison with nondiabetic healthy<br />individuals. </span><span class="fontstyle0">Materials and Methods: </span><span class="fontstyle2">Tis cross?sectional study was comprised of 150 individuals grouped in three, namely, Group A (</span><span class="fontstyle3">n </span><span class="fontstyle2">= 60) healthy volunteers, Group B (</span><span class="fontstyle3">n </span><span class="fontstyle2">= 30) newly diagnosed diabetes, and Group C (</span><span class="fontstyle3">n </span><span class="fontstyle2">= 60) diabetes treated with OAD. Serum malondialdehyde (MDA), nitric oxide (NO), and Vitamin C were assessed for studying lipid peroxidation status, whereas serum triglyceride (TG) and total cholesterol were monitored as predictors for CV risk. </span><span class="fontstyle0">Results: </span><span class="fontstyle2">We found signifcantly higher concentrations of MDA and NO levels (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.001) in both groups of patients (Group B and C) in comparison to control group (Group A). Regarding antioxidants, signifcantly lower concentrations of Vitamin C (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.046) were found in Group B and C compared to Group A. Moreover, there was signifcant di?erence exhibited in concentration level of MDA (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.001) and NO (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.015) between Group B and C, whereas di?erence of Vitamin C (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.147) was not statistically signifcant. </span><span class="fontstyle0">Conclusions: </span><span class="fontstyle2">Our data confrmed that<br />treatment with gliclazide and metformin signifcantly reduced the lipid peroxidation accompanied with attenuated levels of serum TGs and cholesterol and suggested that oral hypoglycemic agents have great impact to reduce the oxidative stress and increase the<br />antioxidant status in diabetes. </span> <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10822http://jrms.mui.ac.ir/index.php/jrms/article/download/10822/5660