Journal of Research in Medical Sciences1735-1995237201807281081410814EN20180728<span class="fontstyle0">Background: </span><span class="fontstyle2">In this study, we aimed to retrospectively evaluate treatment outcomes and treatment methods in acromegaly patients. </span><span class="fontstyle0">Materials and Methods: </span><span class="fontstyle2">Te study included 65 acromegaly patients followed in Sakarya University Faculty of Medicine Department of Endocrinology in Turkey between 2004 and 2013. Clinical, biochemical, and radiological data were obtained retrospectively from the medical fles of the patients. All cases have been discussed in the endocrinology and pituitary surgery council, and a multidisciplinary treatment approach had been chosen in  management. </span><span class="fontstyle0">Results: </span><span class="fontstyle2">Sixty?fve patients were included in the study. Of the patients, 57% were female. Mean age was 45.3 ± 9.2 years old. Of the cases, 12.3% were microadenomas (</span><span class="fontstyle3">n </span><span class="fontstyle2">= 8, tumor diameter &lt;10 mm) and 87.6% were macroadenomas (</span><span class="fontstyle3">n </span><span class="fontstyle2">= 57, tumor diameter ?10 mm). In our study, 70% remission was achieved with the frst operation and medical<br />treatment. Patients with invasive acromegaly without remission after the frst operation underwent reoperation, medical treatment, and conventional or stereotactic radiotherapy and achieved 45% remission rate. </span><span class="fontstyle0">Conclusion: </span><span class="fontstyle2">Pituitary surgery is the frst treatment option for acromegaly. In patients who could not be remissioned after the frst operation, remission can be achieved by combined therapy consist of reoperation, medical treatment, and conventional or stereotactic radiotherapy.</span>http://jrms.mui.ac.ir/index.php/jrms/article/view/10814http://jrms.mui.ac.ir/index.php/jrms/article/download/10814/5651