Journal of Research in Medical Sciences1735-1995232201802241075510755EN20180224<span class="fontstyle0">Background: </span><span class="fontstyle2">Metabolic control is a major concern in preventing diabetic complications. Sa?ron as a natural source of antioxidants </span><table class="NormalTable"><tbody><tr><td width="550"><span class="fontstyle2">could play a role in alleviating diabetes insults. Te aim of this study was to investigate e?ect of sa?ron hydroalcoholic extract on metabolic control in type 2 diabetes (T2D) mellitus. </span><span class="fontstyle0">Materials and Methods: </span><span class="fontstyle2">Tis randomized triple blind study was included 54 T2D patients which randomly received either sa?ron (Group 1) or placebo (Group 2) twice daily other than routine antidiabetic treatments for 8 weeks. Serum concentration of fasting blood sugar (FBS), 2?h plasma glucose, hemoglobin A1c (HbA1c), total  cholesterol, triglyceride (TG), low?density lipoprotein, and high?density  lipoprotein were measured as the markers of metabolic control.   Anthropometric measures and blood pressure were also measured at the baseline, every 2 weeks during the intervention and the end of the study. Data analyzed using repeated measure analysis of variance test. </span><span class="fontstyle0">Results: </span><span class="fontstyle2">Te baseline metabolic parameters were the same in two group (</span><span class="fontstyle3">P </span><span class="fontstyle2">&gt; 0.01). FBS serum level signifcantly decreased within 8 weeks in the sa?ron group (128.84 ± 31.86) as compared to the placebo (153.76 ± 41.23), (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.001). Tere was no statistical di?erence in other metabolic parameters such as serum lipids, blood pressure, and HbA1c (</span><span class="fontstyle3">P </span><span class="fontstyle2">&gt; 0.01). </span><span class="fontstyle0">Conclusion: </span><span class="fontstyle2">Sa?ron hydroalcoholic extract may improve blood glucose control by  reducing FBS in T2D patients. However, sa?ron extract has no signifcant e?ect on other aspects of diabetic control in diabetic patients.</span></td></tr></tbody></table> <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10755http://jrms.mui.ac.ir/index.php/jrms/article/download/10755/5596