Journal of Research in Medical Sciences1735-1995231201802031075410754EN20180203<span class="fontstyle0">Background: </span><span class="fontstyle2">In this study, the e?ect of testosterone gel administration during ovulation induction on the fertility rate was examined in women with a poor ovarian response in </span><span class="fontstyle3">in vitro </span><span class="fontstyle2">fertilization (IVF) cycles. </span><span class="fontstyle0">Materials and Methods: </span><span class="fontstyle2">Te current study is a single?blinded, randomized clinical trial. Patients who met inclusion (Bologna) criteria were placed in the antagonist cycle group. Te patients were randomly divided into two groups each  included 25 participants treated with a placebo (lubricant gel, the controls)<br />and testosterone gel (intervention). Fertility outcomes were compared between two study groups. </span><span class="fontstyle0">Results: </span><span class="fontstyle2">Te mean ± standard deviation (SD) age of intervention (41.04 ± 3.77) versus control group (39.69 ± 3.29) was not statistically di?erent. Te two studied groups were not statistically di?erent in terms of follicle?stimulating hormone; antral follicle count, IVF, anti?Mullerian hormone, and the duration of infertility. Te mean ± SD of oocyte 2.48 ± 1.64 versus 1.17 ± 1.27 and embryo 1.60 ± 1.58 versus 0.39 ± 0.58 in intervention group was signifcantly higher than control group (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.01). Te rate of pregnancy 16% versus 0% and embryo of quality<br />A–B was signifcantly higher in intervention group than control (60% versus 17.4%, </span><span class="fontstyle3">P </span><span class="fontstyle2">&lt; 0.05). </span><span class="fontstyle0">Conclusion: </span><span class="fontstyle2">Te results of the current study showed that the testosterone gel has a signifcant impact on the fertility rate in women with a poor response in the IVF cycles. Further, randomized clinical trials with larger sample sized are recommended.</span> <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10754http://jrms.mui.ac.ir/index.php/jrms/article/download/10754/5643