Journal of Research in Medical Sciences1735-1995231201802031075210752EN20180203<span class="fontstyle0">Background: </span><span class="fontstyle2">Peptic ulcer is a prevalent problem and symptoms include epigastria pain and heartburn. Tis study aimed at investigating the prevalence and causes of peptic ulcers in Iran using systematic review and meta-analysis. </span><span class="fontstyle0">Materials and Methods: </span><span class="fontstyle2">Eleven Iranian papers published from 2002 to 2016 are selected using valid keywords in the SID, Goggle scholar, PubMed and Elsevier databases. Results of studies pooled using random e?ects model in meta-analysis.Te heterogeneity of the sample was checked using Q test and </span><span class="fontstyle3">I</span><span class="fontstyle2" style="font-size: 5pt;">2 </span><span class="fontstyle2">index. </span><span class="fontstyle0">Results: </span><span class="fontstyle2">Total sample size in this study consist of 1335 individuals with peptic ulcer (121 samples per article). Te prevalence of peptic ulcers was estimated 34% (95% CI= 0.25 – 0.43). Te prevalence of peptic ulcers was 30% and 60% in woman and man respectively. Te highest environmental factor (cigarette) has been  addressed in 30% (95% CI= 0.23-0.37) of patients. Te prevalence of Helicobacter pylori was estimated in 62% (95% CI= 0.49-0.75) of patients. </span><span class="fontstyle0">Conclusion: </span><span class="fontstyle2">Te results of this study show that prevalence of peptic ulcers in Iran (34%) is higher that worldwide rate (6% to 15%). Tere was an  increasing trend in the prevalence of peptic ulcer over a decade from 2002 to 2016. </span> <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10752http://jrms.mui.ac.ir/index.php/jrms/article/download/10752/5592