Journal of Research in Medical Sciences1735-19952211201712031072110721EN20171115<span class="fontstyle0">Context</span><span class="fontstyle1">: Allergic rhinitis (AR) is one of the health problems in the world. It is necessary to develop new treatment procedure </span><span class="fontstyle1" style="color: #231f20;">for control of this  disease. </span><span class="fontstyle0" style="color: #231f20;">Aims</span><span class="fontstyle1" style="color: #231f20;">: Te aim of this study was to assess the effect of </span><span class="fontstyle3">Zofa </span><span class="fontstyle1" style="color: #231f20;">(</span><span class="fontstyle3">Nepeta bracteata </span><span class="fontstyle1" style="color: #231f20;">Benth) on AR patients. </span><span class="fontstyle0" style="color: #231f20;">Settings and Design: </span><span class="fontstyle1">???. </span><span class="fontstyle0" style="color: #231f20;">Materials and Methods: </span><span class="fontstyle1" style="color: #231f20;">In this double-blind randomized clinical trial study, 71 patients (37 patients in treatment and 34 in placebo group) participated. In treatment group, </span><span class="fontstyle3">N. bracteata </span><span class="fontstyle1" style="color: #231f20;">syrup (NBS) was used for 4 weeks as three times a day. Te efficacy of the drug regarding AR symptoms (rhinorrhea, sneezing, nasal obstruction, itchy nose, and ocular symptoms) were evaluated through a visual analog scale (VAS) by 0–10 before administration and at the end of the whole treatment period.<br /></span><span class="fontstyle0" style="color: #231f20;">Statistical Analysis Used: </span><span class="fontstyle1" style="color: #231f20;">Te collected information was entered in the SPSS software (version 18) and was analyzed using the Fisher’s exact test, Chi-square test, independent sample </span><span class="fontstyle3">t</span><span class="fontstyle1" style="color: #231f20;">-test, and paired sample test. </span><span class="fontstyle0" style="color: #231f20;">Results: </span><span class="fontstyle1" style="color: #231f20;">Te improvement of AR symptoms in the group receiving NBS was significantly higher compared to control group (4.73 ± 1.84 vs. 0.38 ± 2.06; </span><span class="fontstyle3">P </span><span class="fontstyle1" style="color: #231f20;">&lt; 0.0001). Furthermore, the mean of total VAS before and after the treatment (in case group) was 7.10 ± 1.92 and 2.37 ± 1.76, respectively (</span><span class="fontstyle3">P </span><span class="fontstyle1" style="color: #231f20;">&lt; 0.001). </span><span class="fontstyle0" style="color: #231f20;">Conclusion: </span><span class="fontstyle1" style="color: #231f20;">Te results of this study indicate that </span><span class="fontstyle3">N. bracteata </span><span class="fontstyle1" style="color: #231f20;">has significant effects on improving the symptoms of AR. Hence, it can be a good alternative to AR symptoms relief. </span> <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10721http://jrms.mui.ac.ir/index.php/jrms/article/download/10721/5569