Journal of Research in Medical Sciences1735-19952211201712031072010720EN20171115<span class="fontstyle0">Background: </span><span class="fontstyle2">Recent studies hypothesize that dyslipidemia can predict glycated hemoglobin (HbA1c) and could be important contributing factor to the pathogenesis of type 2 diabetes mellitus (DM2). Terefore, we aimed to evaluate the in?uence of lipidparameters on long?term glycemic control in DM2. </span><span class="fontstyle0">Materials and Methods: </span><span class="fontstyle2">A total of 275 sedentary DM2 (mean [±standarddeviation] age 60.6 [±10.0] years) who volunteered toparticipate in this cross?sectional study were enrolled. Anthropometric (bodyweight, body hight, and waist circumference), biochemical parameters (fasting glucose, HbA1c, lipid parameters, creatinine), aswell as blood pressure were obtained. </span><span class="fontstyle0">Results: </span><span class="fontstyle2">Total cholesterol (odds ratio [OR] =1.30, 95% confdence interval [CI] [1.02–1.66],</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.032), triglycerides (OR = 1.34, 95% CI (1.07–1.67), </span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.010), and low density lipoprotein cholesterol (OR = 1.42, 95%CI [1.10–1.83], </span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.006) were the independent predictors of higher HBA1c, and as they increased by 1 mmol/L each, probabilitiesof higher HBA1c increased by 30%, 34%, and 42%, respectively. Low level of high?density lipoprotein cholesterol (HDL?c) was foundto be the independent predictor of higher HBA1c (OR = 0.44, 95% CI [0.20–0.67], </span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.039), and increase in HDL?c by 1 mmol/L,reduced the probability of higher HBA1c by 56%. </span><span class="fontstyle0">Conclusion: </span><span class="fontstyle2">Unfavorable lipid profle can predict HbA1c level in DM2 patients.Early diagnosis of dyslipidemia, as well as its monitoring and maintaining good lipids control can be used as a preventive measurefor optimal long?term glycemic control.</span> <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10720http://jrms.mui.ac.ir/index.php/jrms/article/download/10720/5567