Effect of Vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto’s thyroiditis: A double?blind randomized placebo?controlled clinical trial

Journal of Research in Medical Sciences1735-199522920170927Effect of Vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto’s thyroiditis: A double?blind randomized placebo?controlled clinical trial1069610696EN20170724<table class="NormalTable"><tbody><tr><td width="550">Background: Te link between autoimmune thyroid diseases and Vitamin D defciency has been reported. However, there are controversies in this regard. We conducted a double?blind randomized placebo?controlled clinical trial to investigate the e?ect of Vitamin D defciency treatment on thyroid function and autoimmunity marker (thyroid peroxidase antibody [TPO?Ab]) in patients with Hashimoto’s thyroiditis. Materials and Methods: ifty?six patients with Hashimoto’s thyroiditis and Vitamin D defciency (25?hydroxyvitamin D level ?20 ng/mL) were randomly allocated into two groups to receive Vitamin D (50000 IU/week, orally) or placebo for 12 weeks, as Vitamin D?treated (n = 30) and control (n = 26) groups, respectively. TPO?Ab, thyroid?stimulating hormone (TSH), parathormone, calcium, albumin, and creatinine concentrations were compared before and after trial between and within groups. Te data were presented as mean (standard error [SE]) and analyzed by appropriate tests. Results: Mean (SE) of Vitamin D was increased in Vitamin D?treated group (45.5 [1.8] ng/mL vs. 12.7 [0.7] ng/mL, P = 0.01). Mean (SE) of TPO?Ab did not signifcantly change in both groups (734 [102.93] IU/mL vs. 820.25 [98.92] IU/mL, P = 0.14 in Vitamin D?treated and 750.03 [108.7] [IU/mL] vs. 838.07 [99.4] [IU/mL] in placebo?treated group, P = 0.15). Mean (SE) of TSH was not changed in both groups after trial, P = 0.4 and P = 0.15 for Vitamin D?treated and control groups, respectively. No signifcant di?erence was observed between two study groups in none studied variables (P > 0.05). Conclusion: Vitamin D treatment in Vitamin D defcient patients with Hashimoto’s thyroiditis could not have signifcant e?ect on thyroid function and autoimmunity. </td></tr></tbody></table><br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10696http://jrms.mui.ac.ir/index.php/jrms/article/download/10696/5553