Journal of Research in Medical Sciences1735-1995229201709271069310693EN20170724<span class="fontstyle0">Background: </span><span class="fontstyle2">In?ammatory bowel disease (IBD) has a signifcant impact on health?related quality of life (HRQOL). Tis study aims to investigate the  variables which can be attributed to HRQOL in IBD patients. </span><span class="fontstyle0">Materials and Methods: </span><span class="fontstyle2">Seventy?one patients flled in IBD questionnaire (IBDQ?32),  Pittsburgh sleep quality index questionnaire, and sociodemographic questionnaire. Disease activity was assessed by Crohn’s disease activity  index (CDAI) and ulcerative colitis activity index (UCAI). Te correlations of sleep quality, sociodemographic variables, and disease characteristics with IBDQ were investigated. </span><span class="fontstyle0">Results: </span><span class="fontstyle2">IBDQ?32 mean score was lower in patients who had hospitalization (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.01), poor sleep quality (</span><span class="fontstyle3">P </span><span class="fontstyle2">&lt;  0.001), anemia (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.03), more severe disease (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.01), and those who had not consumed folic acid (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.01) relative to their counterparts. A multivariate regression analysis identifed the predictors of decreased  HRQOL as not consuming folic acid (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.008), poor sleep quality (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.014), and disease severity (</span><span class="fontstyle3">P </span><span class="fontstyle2">= 0.043). </span><span class="fontstyle0">Conclusions: </span><span class="fontstyle2">Impaired HRQOL was signifcantly associated with poor sleep quality, lack of folic acid  consumption, and disease severity in IBD patients. Terefore, evaluation of folic acid level and efcacy of its supplementation in prospective studies is recommended. Treatment of sleep disturbance with pharmacological agents and nonpharmacological methods should be kept in mind as well.</span><span class="fontstyle2"> </span> <br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px;" />http://jrms.mui.ac.ir/index.php/jrms/article/view/10693http://jrms.mui.ac.ir/index.php/jrms/article/download/10693/5552