<p>Sir,</p> <p>We read with great interest the published article in the esteemed ′Journal of Research in Medical Sciences′, by Hemati et al., entitled, "The effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study". In 22 cancerous patients, who received 400 IU vitamin E and 200 μg selenium daily and 24 patients, who received placebo, they found that vitamin E and selenium can be used to reduce cisplatin-induced nephrotoxicity and bone marrow suppression. <sup> <xref ref-type="bibr" rid="ref1">1</xref> </sup>In this paper, we would like to mention a few points about kidney protective efficacy of selenium. Renal injury is common following cisplatin infusion. <sup> <xref ref-type="bibr" rid="ref2">2</xref>.</sup>Recently, in a double-blind controlled randomized clinical trial, we studied 122 cancerous patients (85 male and 37 female; age range of 14-82 years old) who were candidate to receive chemotherapy regimens consisting cisplatin. They were allocated into two groups using a randomized numbered list. Intervention group received a 400 mcg selenium tablet/day and patients in control group took a placebo tablet/day. Primary end points were an increase in plasma creatinine above 1.5 mg/dl in men and 1.4 mg/dl in women, or increase of plasma creatinine more than 50% from baseline or urine flow rate less than 0.5 ml/kg/h. Serum creatinine level was measured initially and on the 5 <sup>th</sup>day after cisplatin therapy. In our study, in case group no laboratory signs of kidney injury were observed, while among placebo group, seven patients had criteria of acute kidney injury. We concluded that selenium could probably prevent cisplatin-induced acute kidney injury, when it is added to hydration therapy in cancerous patients. <sup> <xref ref-type="bibr" rid="ref3">3</xref> </sup>Recently, much attention has been made toward kidney protective efficiency of selenium. The results of the study conducted by Randjelovic et al., showed selenium supplementation attenuates oxidative-stress-associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats, <sup> <xref ref-type="bibr" rid="ref4">4</xref> </sup>while gentamicin-renal damage in Wistar rats is a model of acute kidney injury indicated that gentamicin-induced tissue injury was mediated through oxidative reactions. <sup> <xref ref-type="bibr" rid="ref5">5</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref6">6</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref7">7</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref8">8</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref9">9</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref10">10</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref11">11</xref> </sup>Selenium is a trace element that participates as a cofactor in several enzymes, one of them is participant in the regulation of enzymatic antioxidant defenses. <sup> <xref ref-type="bibr" rid="ref12">12</xref> </sup>It was found that selenium supplementation in renal patients reduce the products of oxidative stress. <sup> <xref ref-type="bibr" rid="ref12">12</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref13">13</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref14">14</xref> </sup>In a study by Taskin et al., on adriamycin-induced renal damage in rats showed selenium is effective in vivo against adriamycin-induced kidney injury via the restoration of total antioxidant and oxidant status, which prevented mitochondrial damage. <sup> <xref ref-type="bibr" rid="ref15">15</xref> </sup>Recent findings have shown that plasma selenium level have been found to be reduced in patients with acute kidney injury. <sup> <xref ref-type="bibr" rid="ref16">16</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref17">17</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref18">18</xref> </sup>indeed, low serum selenium levels are a frequent finding in patients with chronic renal failure too. <sup> <xref ref-type="bibr" rid="ref19">19</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref20">20</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref21">21</xref> </sup>However, to date, few investigations have studied the association of hyposelenemia and morbidity and mortality in renal failure patients. Thus, these available data lend further evidence for the attribution of selenium in its kidney protective property. In this regard, to understand the selenium kidney protective properties better, more experimental rat models or clinical studies are suggested.</p> </sec> </body> <back> <ref-list> <ref id="ref1"> <label>1</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Hemati</surname> <given-names>S</given-names> </name> <name> <surname>Arbab</surname> <given-names>JN</given-names> </name> <name> <surname>Rafienia</surname> <given-names>M</given-names> </name> <name> <surname>Ghavamnasiri</surname> <given-names>M</given-names> </name> </person-group> <article-title>The effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study</article-title> <source>J Res Med Sci</source> <year>2012</year> <volume>17</volume> <fpage>S49</fpage> <lpage>58</lpage> </nlm-citation> </ref> <ref id="ref2"> <label>2</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Nematbakhsh</surname> <given-names>M</given-names> </name> <name> <surname>Ashrafi</surname> <given-names>F</given-names> </name> <name> <surname>Pezeshki</surname> <given-names>Z</given-names> </name> <name> <surname>Fatahi</surname> <given-names>Z</given-names> </name> <name> <surname>Kianpoor</surname> <given-names>F</given-names> </name> <name> <surname>Sanei</surname> <given-names>MH</given-names> </name> <etal /> </person-group> <article-title>A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model</article-title> <source>J Nephropathology</source> <year>2012</year> <volume>1</volume> <fpage>190</fpage> <lpage>3</lpage> </nlm-citation> </ref> <ref id="ref3"> <label>3</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Ghorbani</surname> <given-names>A</given-names> </name> <name> <surname>Omidvar</surname> <given-names>B</given-names> </name> <name> <surname>Parsi</surname> <given-names>A</given-names> </name> </person-group> <article-title>Protective effect of selenium on cisplatin induced nephrotoxicity: A double-blind controlled randomized clinical trial</article-title> <source>J Nephropathology</source> <year>2013</year> <volume>2</volume> <fpage>129</fpage> <lpage>34</lpage> </nlm-citation> </ref> <ref id="ref4"> <label>4</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Randjelovic</surname> <given-names>P</given-names> </name> <name> <surname>Veljkovic</surname> <given-names>S</given-names> </name> <name> <surname>Stojiljkovic</surname> <given-names>N</given-names> </name> <name> <surname>Velickovic</surname> <given-names>L</given-names> </name> <name> <surname>Sokolovic</surname> <given-names>D</given-names> </name> <name> <surname>Stoiljkovic</surname> <given-names>M</given-names> </name> <etal /> </person-group> <article-title>Protective effect of selenium on gentamicin-induced oxidative stress and nephrotoxicity in rats</article-title> <source>Drug Chem Toxicol</source> <year>2012</year> <volume>35</volume> <fpage>141</fpage> <lpage>8</lpage> </nlm-citation> </ref> <ref id="ref5"> <label>5</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Ghorbani</surname> <given-names>A</given-names> </name> </person-group> <article-title>Renal protective effect of selenium on cisplatin-induced nephrotoxicity</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>1</volume> <fpage>31</fpage> <lpage>2</lpage> </nlm-citation> </ref> <ref id="ref6"> <label>6</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Tavaﬁ</surname> <given-names>M</given-names> </name> </person-group> <article-title>Inhibition of gentamicin-induced renal tubular cell necrosis</article-title> <source>J Nephropathology</source> <year>2012</year> <volume>1</volume> <fpage>83</fpage> <lpage>8</lpage> </nlm-citation> </ref> <ref id="ref7"> <label>7</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Tavafi</surname> <given-names>M</given-names> </name> </person-group> <article-title>Protection of renal tubules against gentamicin induced nephrotoxicity</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>2</volume> <fpage>5</fpage> <lpage>6</lpage> </nlm-citation> </ref> <ref id="ref8"> <label>8</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Khajehdehi</surname> <given-names>P</given-names> </name> </person-group> <article-title>Turmeric: Reemerging of a neglected Asian traditional remedy</article-title> <source>J Nephropathology</source> <year>2012</year> <volume>11</volume> <fpage>7</fpage> <lpage>22</lpage> </nlm-citation> </ref> <ref id="ref9"> <label>9</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Nasri</surname> <given-names>H</given-names> </name> </person-group> <article-title>Acute kidney injury and beyond</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>1</volume> <fpage>1</fpage> <lpage>2</lpage> </nlm-citation> </ref> <ref id="ref10"> <label>10</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Baradaran</surname> <given-names>A</given-names> </name> <name> <surname>Mahmoud Rafieian-kopaei</surname> <given-names>M</given-names> </name> </person-group> <article-title>Histopathological study of the combination of metformin and garlic juice for the attenuation of gentamicin renal toxicity in rats</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>2</volume> <fpage>15</fpage> <lpage>21</lpage> </nlm-citation> </ref> <ref id="ref11"> <label>11</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Sanadgol</surname> <given-names>H</given-names> </name> <name> <surname>Abdani</surname> <given-names>S</given-names> </name> <name> <surname>Tabatabaiee</surname> <given-names>P</given-names> </name> <name> <surname>Mohammadi</surname> <given-names>M</given-names> </name> </person-group> <article-title>Protective effect of high dose short term statin therapy with normal saline in prevention of contrast-induced nephropathy among iodixanol-receiving patients.J Ren Inj Prev</article-title> <source></source> <year>2013</year> <volume>1</volume> <fpage>43</fpage> <lpage>45</lpage> </nlm-citation> </ref> <ref id="ref12"> <label>12</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Iglesias</surname> <given-names>P</given-names> </name> <name> <surname>Selgas</surname> <given-names>R</given-names> </name> <name> <surname>Romero</surname> <given-names>S</given-names> </name> <name> <surname>Díez</surname> <given-names>JJ</given-names> </name> </person-group> <article-title>Selenium and kidney disease</article-title> <source>J Nephrol</source> <year>2013</year> <volume>26</volume> <fpage>266</fpage> <lpage>72</lpage> </nlm-citation> </ref> <ref id="ref13"> <label>13</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Tavafi</surname> <given-names>M</given-names> </name> </person-group> <article-title>Diabetic nephropathy and antioxidants</article-title> <source>J Nephropathology</source> <year>2013</year> <volume>2</volume> <fpage>20</fpage> <lpage>7</lpage> </nlm-citation> </ref> <ref id="ref14"> <label>14</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Gheissari</surname> <given-names>A</given-names> </name> </person-group> <article-title>Acute kidney injury and renal angina</article-title> <source>J Ren Inj Prev</source> <year>2013</year> <volume>2</volume> <fpage>33</fpage> <lpage>4</lpage> </nlm-citation> </ref> <ref id="ref15"> <label>15</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Taskin</surname> <given-names>E</given-names> </name> <name> <surname>Dursun</surname> <given-names>N</given-names> </name> </person-group> <article-title>The protection of selenium on adriamycin-induced mitochondrial damage in rat</article-title> <source>Biol Trace Elem Res</source> <year>2012</year> <volume>147</volume> <fpage>165</fpage> <lpage>71</lpage> </nlm-citation> </ref> <ref id="ref16"> <label>16</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Gheshlaghi</surname> <given-names>F</given-names> </name> </person-group> <article-title>Toxic renal injury at a glance</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>1</volume> <fpage>15</fpage> <lpage>6</lpage> </nlm-citation> </ref> <ref id="ref17"> <label>17</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Tavafi</surname> <given-names>M</given-names> </name> </person-group> <article-title>Complexity of diabetic nephropathy pathogenesis and design of investigations</article-title> <source>J Ren Inj Prev</source> <year>2013</year> <volume>2</volume> <fpage>61</fpage> <lpage>5</lpage> </nlm-citation> </ref> <ref id="ref18"> <label>18</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Ghorbani</surname> <given-names>A</given-names> </name> </person-group> <article-title>Renal protective effect of selenium on cisplatin-induced nephrotoxicity.J Ren Inj Prev</article-title> <source></source> <year>2013</year> <volume>1</volume> <fpage>31</fpage> <lpage>32</lpage> </nlm-citation> </ref> <ref id="ref19"> <label>19</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Momeni</surname> <given-names>A</given-names> </name> </person-group> <article-title>Serum uric acid and diabetic nephropathy</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>1</volume> <fpage>37</fpage> <lpage>8</lpage> </nlm-citation> </ref> <ref id="ref20"> <label>20</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Jun</surname> <given-names>M</given-names> </name> <name> <surname>Venkataraman</surname> <given-names>V</given-names> </name> <name> <surname>Razavian</surname> <given-names>M</given-names> </name> <name> <surname>Cooper</surname> <given-names>B</given-names> </name> <name> <surname>Zoungas</surname> <given-names>S</given-names> </name> <name> <surname>Ninomiya</surname> <given-names>T</given-names> </name> <etal /> </person-group> <article-title>Antioxidants for chronic kidney disease</article-title> <source>Cochrane Database Syst Rev</source> <year>2012</year> <volume>10</volume> <fpage>CD008176</fpage> </nlm-citation> </ref> <ref id="ref21"> <label>21</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Nasri</surname> <given-names>H</given-names> </name> </person-group> <article-title>Cisplatin and renal injury; current concepts.J Ren Inj Prev</article-title> <source></source> <year>2013</year> <volume>2</volume> <fpage>89</fpage> <lpage>90</lpage> </nlm-citation> </ref> <ref id="ref22"> <label>22</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"></person-group> <article-title></article-title> <source></source> <year></year> <volume></volume> <fpage></fpage> </nlm-citation> </ref> </ref-list> </back> </article>

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J Res Med Sci

Journal of Research in Medical Sciences

1735-1995 1735-7136

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JRMS-18-922

24497869

Letter to Editor

Comment on: The effects of Vitamin E and Selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study

Ghorbani

Ali

Baradaran

Azar

Department of Nephrology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

Address for correspondence:Azar Baradaran, Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran azarbaradaran@yahoo.com

October 2013

18 10 922 923

2013

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

<p>Sir,</p> <p>We read with great interest the published article in the esteemed ′Journal of Research in Medical Sciences′, by Hemati et al., entitled, "The effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study". In 22 cancerous patients, who received 400 IU vitamin E and 200 μg selenium daily and 24 patients, who received placebo, they found that vitamin E and selenium can be used to reduce cisplatin-induced nephrotoxicity and bone marrow suppression. <sup> <xref ref-type="bibr" rid="ref1">1</xref> </sup>In this paper, we would like to mention a few points about kidney protective efficacy of selenium. Renal injury is common following cisplatin infusion. <sup> <xref ref-type="bibr" rid="ref2">2</xref>.</sup>Recently, in a double-blind controlled randomized clinical trial, we studied 122 cancerous patients (85 male and 37 female; age range of 14-82 years old) who were candidate to receive chemotherapy regimens consisting cisplatin. They were allocated into two groups using a randomized numbered list. Intervention group received a 400 mcg selenium tablet/day and patients in control group took a placebo tablet/day. Primary end points were an increase in plasma creatinine above 1.5 mg/dl in men and 1.4 mg/dl in women, or increase of plasma creatinine more than 50% from baseline or urine flow rate less than 0.5 ml/kg/h. Serum creatinine level was measured initially and on the 5 <sup>th</sup>day after cisplatin therapy. In our study, in case group no laboratory signs of kidney injury were observed, while among placebo group, seven patients had criteria of acute kidney injury. We concluded that selenium could probably prevent cisplatin-induced acute kidney injury, when it is added to hydration therapy in cancerous patients. <sup> <xref ref-type="bibr" rid="ref3">3</xref> </sup>Recently, much attention has been made toward kidney protective efficiency of selenium. The results of the study conducted by Randjelovic et al., showed selenium supplementation attenuates oxidative-stress-associated renal injury by reducing oxygen free radicals and lipid peroxidation in gentamicin-treated rats, <sup> <xref ref-type="bibr" rid="ref4">4</xref> </sup>while gentamicin-renal damage in Wistar rats is a model of acute kidney injury indicated that gentamicin-induced tissue injury was mediated through oxidative reactions. <sup> <xref ref-type="bibr" rid="ref5">5</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref6">6</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref7">7</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref8">8</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref9">9</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref10">10</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref11">11</xref> </sup>Selenium is a trace element that participates as a cofactor in several enzymes, one of them is participant in the regulation of enzymatic antioxidant defenses. <sup> <xref ref-type="bibr" rid="ref12">12</xref> </sup>It was found that selenium supplementation in renal patients reduce the products of oxidative stress. <sup> <xref ref-type="bibr" rid="ref12">12</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref13">13</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref14">14</xref> </sup>In a study by Taskin et al., on adriamycin-induced renal damage in rats showed selenium is effective in vivo against adriamycin-induced kidney injury via the restoration of total antioxidant and oxidant status, which prevented mitochondrial damage. <sup> <xref ref-type="bibr" rid="ref15">15</xref> </sup>Recent findings have shown that plasma selenium level have been found to be reduced in patients with acute kidney injury. <sup> <xref ref-type="bibr" rid="ref16">16</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref17">17</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref18">18</xref> </sup>indeed, low serum selenium levels are a frequent finding in patients with chronic renal failure too. <sup> <xref ref-type="bibr" rid="ref19">19</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref20">20</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref21">21</xref> </sup>However, to date, few investigations have studied the association of hyposelenemia and morbidity and mortality in renal failure patients. Thus, these available data lend further evidence for the attribution of selenium in its kidney protective property. In this regard, to understand the selenium kidney protective properties better, more experimental rat models or clinical studies are suggested.</p> </sec> </body> <back> <ref-list> <ref id="ref1"> <label>1</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Hemati</surname> <given-names>S</given-names> </name> <name> <surname>Arbab</surname> <given-names>JN</given-names> </name> <name> <surname>Rafienia</surname> <given-names>M</given-names> </name> <name> <surname>Ghavamnasiri</surname> <given-names>M</given-names> </name> </person-group> <article-title>The effects of vitamin E and selenium on cisplatin-induced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study</article-title> <source>J Res Med Sci</source> <year>2012</year> <volume>17</volume> <fpage>S49</fpage> <lpage>58</lpage> </nlm-citation> </ref> <ref id="ref2"> <label>2</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Nematbakhsh</surname> <given-names>M</given-names> </name> <name> <surname>Ashrafi</surname> <given-names>F</given-names> </name> <name> <surname>Pezeshki</surname> <given-names>Z</given-names> </name> <name> <surname>Fatahi</surname> <given-names>Z</given-names> </name> <name> <surname>Kianpoor</surname> <given-names>F</given-names> </name> <name> <surname>Sanei</surname> <given-names>MH</given-names> </name> <etal /> </person-group> <article-title>A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model</article-title> <source>J Nephropathology</source> <year>2012</year> <volume>1</volume> <fpage>190</fpage> <lpage>3</lpage> </nlm-citation> </ref> <ref id="ref3"> <label>3</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Ghorbani</surname> <given-names>A</given-names> </name> <name> <surname>Omidvar</surname> <given-names>B</given-names> </name> <name> <surname>Parsi</surname> <given-names>A</given-names> </name> </person-group> <article-title>Protective effect of selenium on cisplatin induced nephrotoxicity: A double-blind controlled randomized clinical trial</article-title> <source>J Nephropathology</source> <year>2013</year> <volume>2</volume> <fpage>129</fpage> <lpage>34</lpage> </nlm-citation> </ref> <ref id="ref4"> <label>4</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Randjelovic</surname> <given-names>P</given-names> </name> <name> <surname>Veljkovic</surname> <given-names>S</given-names> </name> <name> <surname>Stojiljkovic</surname> <given-names>N</given-names> </name> <name> <surname>Velickovic</surname> <given-names>L</given-names> </name> <name> <surname>Sokolovic</surname> <given-names>D</given-names> </name> <name> <surname>Stoiljkovic</surname> <given-names>M</given-names> </name> <etal /> </person-group> <article-title>Protective effect of selenium on gentamicin-induced oxidative stress and nephrotoxicity in rats</article-title> <source>Drug Chem Toxicol</source> <year>2012</year> <volume>35</volume> <fpage>141</fpage> <lpage>8</lpage> </nlm-citation> </ref> <ref id="ref5"> <label>5</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Ghorbani</surname> <given-names>A</given-names> </name> </person-group> <article-title>Renal protective effect of selenium on cisplatin-induced nephrotoxicity</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>1</volume> <fpage>31</fpage> <lpage>2</lpage> </nlm-citation> </ref> <ref id="ref6"> <label>6</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Tavaﬁ</surname> <given-names>M</given-names> </name> </person-group> <article-title>Inhibition of gentamicin-induced renal tubular cell necrosis</article-title> <source>J Nephropathology</source> <year>2012</year> <volume>1</volume> <fpage>83</fpage> <lpage>8</lpage> </nlm-citation> </ref> <ref id="ref7"> <label>7</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Tavafi</surname> <given-names>M</given-names> </name> </person-group> <article-title>Protection of renal tubules against gentamicin induced nephrotoxicity</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>2</volume> <fpage>5</fpage> <lpage>6</lpage> </nlm-citation> </ref> <ref id="ref8"> <label>8</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Khajehdehi</surname> <given-names>P</given-names> </name> </person-group> <article-title>Turmeric: Reemerging of a neglected Asian traditional remedy</article-title> <source>J Nephropathology</source> <year>2012</year> <volume>11</volume> <fpage>7</fpage> <lpage>22</lpage> </nlm-citation> </ref> <ref id="ref9"> <label>9</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Nasri</surname> <given-names>H</given-names> </name> </person-group> <article-title>Acute kidney injury and beyond</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>1</volume> <fpage>1</fpage> <lpage>2</lpage> </nlm-citation> </ref> <ref id="ref10"> <label>10</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Baradaran</surname> <given-names>A</given-names> </name> <name> <surname>Mahmoud Rafieian-kopaei</surname> <given-names>M</given-names> </name> </person-group> <article-title>Histopathological study of the combination of metformin and garlic juice for the attenuation of gentamicin renal toxicity in rats</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>2</volume> <fpage>15</fpage> <lpage>21</lpage> </nlm-citation> </ref> <ref id="ref11"> <label>11</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Sanadgol</surname> <given-names>H</given-names> </name> <name> <surname>Abdani</surname> <given-names>S</given-names> </name> <name> <surname>Tabatabaiee</surname> <given-names>P</given-names> </name> <name> <surname>Mohammadi</surname> <given-names>M</given-names> </name> </person-group> <article-title>Protective effect of high dose short term statin therapy with normal saline in prevention of contrast-induced nephropathy among iodixanol-receiving patients.J Ren Inj Prev</article-title> <source></source> <year>2013</year> <volume>1</volume> <fpage>43</fpage> <lpage>45</lpage> </nlm-citation> </ref> <ref id="ref12"> <label>12</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Iglesias</surname> <given-names>P</given-names> </name> <name> <surname>Selgas</surname> <given-names>R</given-names> </name> <name> <surname>Romero</surname> <given-names>S</given-names> </name> <name> <surname>Díez</surname> <given-names>JJ</given-names> </name> </person-group> <article-title>Selenium and kidney disease</article-title> <source>J Nephrol</source> <year>2013</year> <volume>26</volume> <fpage>266</fpage> <lpage>72</lpage> </nlm-citation> </ref> <ref id="ref13"> <label>13</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Tavafi</surname> <given-names>M</given-names> </name> </person-group> <article-title>Diabetic nephropathy and antioxidants</article-title> <source>J Nephropathology</source> <year>2013</year> <volume>2</volume> <fpage>20</fpage> <lpage>7</lpage> </nlm-citation> </ref> <ref id="ref14"> <label>14</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Gheissari</surname> <given-names>A</given-names> </name> </person-group> <article-title>Acute kidney injury and renal angina</article-title> <source>J Ren Inj Prev</source> <year>2013</year> <volume>2</volume> <fpage>33</fpage> <lpage>4</lpage> </nlm-citation> </ref> <ref id="ref15"> <label>15</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Taskin</surname> <given-names>E</given-names> </name> <name> <surname>Dursun</surname> <given-names>N</given-names> </name> </person-group> <article-title>The protection of selenium on adriamycin-induced mitochondrial damage in rat</article-title> <source>Biol Trace Elem Res</source> <year>2012</year> <volume>147</volume> <fpage>165</fpage> <lpage>71</lpage> </nlm-citation> </ref> <ref id="ref16"> <label>16</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Gheshlaghi</surname> <given-names>F</given-names> </name> </person-group> <article-title>Toxic renal injury at a glance</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>1</volume> <fpage>15</fpage> <lpage>6</lpage> </nlm-citation> </ref> <ref id="ref17"> <label>17</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Tavafi</surname> <given-names>M</given-names> </name> </person-group> <article-title>Complexity of diabetic nephropathy pathogenesis and design of investigations</article-title> <source>J Ren Inj Prev</source> <year>2013</year> <volume>2</volume> <fpage>61</fpage> <lpage>5</lpage> </nlm-citation> </ref> <ref id="ref18"> <label>18</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Ghorbani</surname> <given-names>A</given-names> </name> </person-group> <article-title>Renal protective effect of selenium on cisplatin-induced nephrotoxicity.J Ren Inj Prev</article-title> <source></source> <year>2013</year> <volume>1</volume> <fpage>31</fpage> <lpage>32</lpage> </nlm-citation> </ref> <ref id="ref19"> <label>19</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Momeni</surname> <given-names>A</given-names> </name> </person-group> <article-title>Serum uric acid and diabetic nephropathy</article-title> <source>J Ren Inj Prev</source> <year>2012</year> <volume>1</volume> <fpage>37</fpage> <lpage>8</lpage> </nlm-citation> </ref> <ref id="ref20"> <label>20</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Jun</surname> <given-names>M</given-names> </name> <name> <surname>Venkataraman</surname> <given-names>V</given-names> </name> <name> <surname>Razavian</surname> <given-names>M</given-names> </name> <name> <surname>Cooper</surname> <given-names>B</given-names> </name> <name> <surname>Zoungas</surname> <given-names>S</given-names> </name> <name> <surname>Ninomiya</surname> <given-names>T</given-names> </name> <etal /> </person-group> <article-title>Antioxidants for chronic kidney disease</article-title> <source>Cochrane Database Syst Rev</source> <year>2012</year> <volume>10</volume> <fpage>CD008176</fpage> </nlm-citation> </ref> <ref id="ref21"> <label>21</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Nasri</surname> <given-names>H</given-names> </name> </person-group> <article-title>Cisplatin and renal injury; current concepts.J Ren Inj Prev</article-title> <source></source> <year>2013</year> <volume>2</volume> <fpage>89</fpage> <lpage>90</lpage> </nlm-citation> </ref> <ref id="ref22"> <label>22</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"></person-group> <article-title></article-title> <source></source> <year></year> <volume></volume> <fpage></fpage> </nlm-citation> </ref> </ref-list> </back> </article>