<p>Sir,</p> <p>Recent studies investigated on effectiveness of Ipratropium and Salmeterol - Fluticason (SFC) in chronic obstructive pulmonary disease (COPD) patients. Some of these investigations revealed these increased O <sub>2</sub>saturation (SaO <sub>2</sub>) in duration sleep and increased quality of life. <sup> <xref ref-type="bibr" rid="ref1">1</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref2">2</xref> </sup>Thus, we decided to evaluate and compare the effect of Ipratropium bromide and SFC on SaO <sub>2</sub>in patients suffered by COPD.</p> <p>We selected 35 COPD patients who referred to Firuzgar hospital in 2009. Participants randomized by computer generated, and then participants treated with Ipratropium bromide (40 μg/QID) or SFC (50/250 mg/BD) under crossover randomization. Each participant was followed for two days, and then treatment stopped for two days. After this, each study group received another medication for two days. We measured SaO <sub>2</sub>by fingertip pulsoxymeter, in two groups before and after 15, 30, 60, and 180 min inhalation of SFC or Ipratropium bromide. A repeated-measures analysis of variances was performed to compare the ability of each of the medication to increase SaO <sub>2</sub>before and after medication. We revealed both of Ipratropium and SFC increased SaO <sub>2</sub>, but Ipratropium bromide inhalation was more effective than SFC to increasing O <sub>2</sub>saturation after 30 min inhalation these drugs. Our findings indicated that both Ipratropium and SFC increased SaO <sub>2</sub>, but inhaled Ipratropium bromide was more effective than SFC to increase SaO <sub>2</sub>but 30 min after inhalation of these drugs.</p> </sec> </body> <back> <ref-list> <ref id="ref1"> <label>1</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Amra</surname> <given-names>B</given-names> </name> <name> <surname>Golshan</surname> <given-names>M</given-names> </name> <name> <surname>Fietze</surname> <given-names>I</given-names> </name> <name> <surname>Penzel</surname> <given-names>T</given-names> </name> <name> <surname>Welte</surname> <given-names>T</given-names> </name> </person-group> <article-title>Correlation between chronic obstructive pulmonary disease and obstructive sleep apnea syndrome in a general population in Iran</article-title> <source>J Res Med Sci</source> <year>2011</year> <volume>16</volume> <fpage>885</fpage> <lpage>9</lpage> </nlm-citation> </ref> <ref id="ref2"> <label>2</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Martin</surname> <given-names>RJ</given-names> </name> <name> <surname>Bartelson</surname> <given-names>BL</given-names> </name> <name> <surname>Smith</surname> <given-names>P</given-names> </name> <name> <surname>Hudgel</surname> <given-names>DW</given-names> </name> <name> <surname>Lewis</surname> <given-names>D</given-names> </name> <name> <surname>Pohl</surname> <given-names>G</given-names> </name> <etal /> </person-group> <article-title>Effect of ipratropium bromide treatment on oxygen saturation and sleep quality in COPD</article-title> <source>Chest</source> <year>1999</year> <volume>115</volume> <fpage>1338</fpage> <lpage>45</lpage> </nlm-citation> </ref> <ref id="ref3"> <label>3</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"></person-group> <article-title></article-title> <source></source> <year></year> <volume></volume> <fpage></fpage> </nlm-citation> </ref> </ref-list> </back> </article>

JRMS

J Res Med Sci

Journal of Research in Medical Sciences

1735-1995 1735-7136

Medknow Publications Pvt Ltd

India

JRMS-18-731

24379853

Letter to Editor

Ipratropium bromide is more effective than Salmeterol - Fluticason combination on O ₂saturation patients with COPD

Rezaie

Nader

Shams-Hosseini

Narges S

Kashanizadeh

Atefeh

Karimi

Mohammad A

Department of Pulmonary Disease, Tehran University of Medical Science, Tehran, Iran Department of Pulmonary Disease, Tehran University of Medical Science, Tehran, Iran Department of Pulmonary Disease, Tehran University of Medical Science, Tehran, Iran Department of Pulmonary Disease, Tehran University of Medical Science, Tehran, Iran

Address for correspondence:Nader Rezaie, Department of Pulmonary Disease, Tehran University of Medical Science, Tehran, Iran drnader48@gmail.com

August 2013

18 8 731 731

2013

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

<p>Sir,</p> <p>Recent studies investigated on effectiveness of Ipratropium and Salmeterol - Fluticason (SFC) in chronic obstructive pulmonary disease (COPD) patients. Some of these investigations revealed these increased O <sub>2</sub>saturation (SaO <sub>2</sub>) in duration sleep and increased quality of life. <sup> <xref ref-type="bibr" rid="ref1">1</xref> </sup>, <sup> <xref ref-type="bibr" rid="ref2">2</xref> </sup>Thus, we decided to evaluate and compare the effect of Ipratropium bromide and SFC on SaO <sub>2</sub>in patients suffered by COPD.</p> <p>We selected 35 COPD patients who referred to Firuzgar hospital in 2009. Participants randomized by computer generated, and then participants treated with Ipratropium bromide (40 μg/QID) or SFC (50/250 mg/BD) under crossover randomization. Each participant was followed for two days, and then treatment stopped for two days. After this, each study group received another medication for two days. We measured SaO <sub>2</sub>by fingertip pulsoxymeter, in two groups before and after 15, 30, 60, and 180 min inhalation of SFC or Ipratropium bromide. A repeated-measures analysis of variances was performed to compare the ability of each of the medication to increase SaO <sub>2</sub>before and after medication. We revealed both of Ipratropium and SFC increased SaO <sub>2</sub>, but Ipratropium bromide inhalation was more effective than SFC to increasing O <sub>2</sub>saturation after 30 min inhalation these drugs. Our findings indicated that both Ipratropium and SFC increased SaO <sub>2</sub>, but inhaled Ipratropium bromide was more effective than SFC to increase SaO <sub>2</sub>but 30 min after inhalation of these drugs.</p> </sec> </body> <back> <ref-list> <ref id="ref1"> <label>1</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Amra</surname> <given-names>B</given-names> </name> <name> <surname>Golshan</surname> <given-names>M</given-names> </name> <name> <surname>Fietze</surname> <given-names>I</given-names> </name> <name> <surname>Penzel</surname> <given-names>T</given-names> </name> <name> <surname>Welte</surname> <given-names>T</given-names> </name> </person-group> <article-title>Correlation between chronic obstructive pulmonary disease and obstructive sleep apnea syndrome in a general population in Iran</article-title> <source>J Res Med Sci</source> <year>2011</year> <volume>16</volume> <fpage>885</fpage> <lpage>9</lpage> </nlm-citation> </ref> <ref id="ref2"> <label>2</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"> <name> <surname>Martin</surname> <given-names>RJ</given-names> </name> <name> <surname>Bartelson</surname> <given-names>BL</given-names> </name> <name> <surname>Smith</surname> <given-names>P</given-names> </name> <name> <surname>Hudgel</surname> <given-names>DW</given-names> </name> <name> <surname>Lewis</surname> <given-names>D</given-names> </name> <name> <surname>Pohl</surname> <given-names>G</given-names> </name> <etal /> </person-group> <article-title>Effect of ipratropium bromide treatment on oxygen saturation and sleep quality in COPD</article-title> <source>Chest</source> <year>1999</year> <volume>115</volume> <fpage>1338</fpage> <lpage>45</lpage> </nlm-citation> </ref> <ref id="ref3"> <label>3</label> <nlm-citation citation-type="journal"> <person-group person-group-type="author"></person-group> <article-title></article-title> <source></source> <year></year> <volume></volume> <fpage></fpage> </nlm-citation> </ref> </ref-list> </back> </article>