Journal of Research in Medical Sciences1735-199517720120515Relation of resistin to obesity and some cardiovascular risk factors in hypertensive female patients73007300ENGülGürsoyDepartement of Internal Medicine, Ankara Education and Research Hospital, Ankara, Turkey. gulgursoyyener@yahoo.comSenaUluYaşarAcarBerrinDemirbaşSüleymanAlkanBirsenErolIşılÖzaşık2011060320120515BACKGROUND: Hypertension and obesity are risk factors of cardiovascular disease. The association between C-reactive protein, homocysteine, microalbuminuria and cardiovascular risk have been debated for decades. Resistin is a newly discovered adipocyte derived cytokine. In the current study we planned to investigate the relation of resistin to these probable cardiovascular risk factors and obesity in hypertensive  patients.METHODS: The study population consisted of 42 non-obese and 42 obese hypertensive females. After making comparisons between C-reactive protein, homocysteine, microalbuminuria and resistin in the two groups, we also sought correlations between all parameters in non-obese and obese groups.RESULTS: In our obese hypertensive group resistin levels were higher than in the non-obese hypertensive group (p < 0.001), but we did not find any difference in other parameters. We found a positive correlation between resistin and C-reactive protein in both non-obese and obese hypertensive groups (in non-obese hypertensives p < 0.05 and in obese hypertensives p < 0.001 ).CONCLUSİONS: We showed that in female obese hypertensive patients resistin levels were higher than in the non-obese patients. We also think that resistin may be associated with C-reactive protein levels but not with homocysteine or microalbuminuria in both non-obese and obese hypertensive patients.  KEYWORDS: Hypertension, Obesity, Resistin, C-reactive Protein, Homocysteine, Microalbuminuria