Journal of Research in Medical Sciences1735-199516420110415Huge retroperitoneal liposarcoma66986698ENMohammad RezaAkhoondinasabDepartment of Surgery, Alzahra Hospital, Isfahan University of Medical Science, Isfahan, Iran. m-akhoondinasab@tums.ac.irMahmoudOmranifard2011012720110408Liposarcoma are one of the common soft tissue sarcomas of adulthood which are remarkable because of their frequently large size. We report a case with an extremely large well-differentiated retroperitoneal liposarcoma that weighted 32 kilograms. The patient had relapse about one year later and two recurrent tumors were successfully excised. KEYWORDS: Liposarcoma, Retroperitoneal space.