Journal of Research in Medical Sciences1735-199511520061226Serum prolactin level in multiple sclerosis patients325328ENMohammad AliShafaAlirezaVakilianDep. of Neurology, Rafsanjan University of Medical Sciences. vakilian_neu@yahoo.comAlirezaPoorebrahimiJafarAhmady Kahnali2006122620061226BACKGROUND: Multiple Sclerosis (MS) is the most common demyelinating disease. An autoimmune basis has been confirmed for pathogenesis of MS. Prolactin (PRL) has roles in these mechanisms. Its serum levels change in MS according to some reports. The purpose of this study was to survey these changes in MS patients. METHODS: Sixty MS patients were included in this cross-sectional study. The same number of controls matched for sex and age were studied. Pregnant, lactating women, consumers of specific medications and patients with underlying diseases were excluded from our study. RIA was used for determination of serum levels of PRL. RESULTS: In this study, PRL level in male patients was 14.23 ± 11.47 ng/ml compared to controls with mean level of 7.21 ± 4.12 ng/ml (P value