Journal of Research in Medical Sciences1735-199515320100104Soft tissue augmentation by autologous cultured fibroblasts transplantation for treatment of wrinkles and scars: a case series of 20 patients167171ENMohammadAliNilforoushzadehAmirHoseinSiadatMojganArian RadSkin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences. arian@sdlrc.mui.ac.irFaribaMoulaviElahehHaftbaradaranMohammadHoseinNasr Esfahani2009061820091103BACKGROUND: There are many filler agents for augmentation of static wrinkles and atrophic scars from synthetic, biosynthetic, cadaver, animal and human sources.METHODS: The current study presents 20 patients whose facial wrinkles and lines were treated by transplantation of autologous cultured fibroblasts. The fibroblast nature of cells was confirmed by immune-staining and flow cytometry.RESULTS: The mean of improvement for this procedure at the 6 month follow up was 41%.CONCLUSIONS: In conclusion autologous fibroblast transplantation can be an effective procedure for correction of wrinkles and atrophic scars.KEYWORDS: Soft Tissue Augmentation, Fibroblast, Wrinkle