Journal of Research in Medical Sciences1735-199511520061226Analysis of lamb lung development with tracheal ligation in left posterolateral diaphragmatic hernia in cases and controls319324ENMahmoudAshrafiSchool of Medicine, Isfahan University of Medical Sciences. ashrafi@med.mui.ac.irMasoudJamshidiMahdiFareedMohmmad HoseinSanei2006031120060820BACKGROUND: When we perform surgery in utero, lungs have an appropriate time to decrease magnitude of hypoplasia, with surgery in uterus. METHODS: Six time-dated single-fetus ewes were selected to induce diaphragmatic hernia. Fetal lambs were divided proportionally into 2 groups, namely group 1, diaphragmatic hernia and tracheal ligation (TL group), and group 2, diaphragmatic hernia only (NL group). Morphologic assessments (weight, volume, bronchiolar branching) and histological tests (lung maturation phase) were performed. RESULTS: Lung weight in relation to lamb weight in the tracheal ligation group differed significantly from the control group (P